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SLC41A1 Antibody

  • 货号：
    CSB-PA810274LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA810274LA01HU diluted at 1:400 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of HepG2 cells with CSB-PA810274LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SLC41A1 Polyclonal antibody
  • Uniprot No.：
    Q8IVJ1
  • 基因名：
    SLC41A1
  • 别名：
    SLC41A1 antibody; Solute carrier family 41 member 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Solute carrier family 41 member 1 protein (1-96AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SLC41A1 Antibody (CSB-PA810274LA01HU)，的标记方式是Non-conjugated。对于SLC41A1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA810274LB01HU SLC41A1 Antibody, HRP conjugated ELISA
    FITC CSB-PA810274LC01HU SLC41A1 Antibody, FITC conjugated
    Biotin CSB-PA810274LD01HU SLC41A1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Na(+)/Mg(2+) ion exchanger that acts as a predominant Mg(2+) efflux system at the plasma membrane. Transporter activity is driven by the inwardly directed electrochemical gradient for Na(+) ions, thus directly depends on the extracellular Na(+) ion concentration set by Na(+)/K(+) pump. Generates circadian cellular Mg(2+) fluxes that feed back to regulate clock-controlled gene expression and metabolism and facilitate higher energetic demands during the day. Has a role in regulating the activity of ATP-dependent enzymes, including those operating in Krebs cycle and the electron transport chain.
  • 基因功能参考文献：
    1. Knockdown of SLC41A1 magnesium transporter promotes mineralization and attenuates magnesium inhibition during osteogenesis of mesenchymal stromal cells. PMID: 28222767
    2. The association of rs11240569 polymorphism in SLC41A1 gene with reduced risk of Parkinson's Disease was replicated in our population. PMID: 27612022
    3. s performed direct DNA sequencing of the SLC41A1 gene in 100 early-onset PD cases. PMID: 26308152
    4. Na+-dependent Mg2+ efflux conducted by Na+/Mg2+ exchanger SLC41A1 is regulated by insulin. PMID: 26355001
    5. This study has shown loss of Mg(2+) efflux function consequent to SLC41A1 R244H variant and SLC41A1 coding variants seem to be rare in Taiwanese Parkinson disease. PMID: 24661466
    6. SLC41A1 is significantly overexpressed in nearly 55% of preeclamptic placentas PMID: 23844728
    7. Binding partners of SLC41A1, were identified. PMID: 23823179
    8. Alanine350Valine substitution in Na/Mg(2) exchanger SLC41A1, potentially associated with Parkinson's disease, is a gain-of-function mutation. PMID: 23976986
    9. In normal human kidney tissue, endogenous SLC41A1 specifically localized to renal tubules situated at the corticomedullary boundary, consistent with the region of cystogenesis observed in nephronophthisis. PMID: 23661805
    10. Direct DNA sequencing of the SLC41A1 and RAB7L1 genes within the PARK16 locus in 205 Chinese Parkinson's disease patients shows no significant difference with controls. PMID: 21812739
    11. The human SLC41A1 gene encodes for the Na+/Mg(2)+ exchanger, the predominant Mg(2)+ efflux system. PMID: 22031603
    12. Results indicate that SLC41A1 proteins are a central component of Mg(2+) transport systems, and that their Mg(2+) transport function is regulated primarily through an endosomal recycling mechanism involving the SLC41A1 N-terminal cytoplasmic domain. PMID: 21696366
    13. Observational study of gene-disease association. (HuGE Navigator) PMID: 20683486
    14. Data report the identification and structural characterization of solute carrier family 41 member 1 (SLC41A1), a eukaryotic protein with homology to the bacterial MgtE family of potential Mg(2+) transporters. PMID: 12810078
    15. The SLC41A1 transcript is present in many tissues, notably renal epithelial cells, and is upregulated in some tissues with magnesium deficiency. PMID: 15713785
    16. SLC41A1 is a novel mammalian Mg2+ carrier PMID: 18367447

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    SLC41A transporter family
  • 组织特异性：
    Highest expression levels in heart and testis, slightly less in skeletal muscles, prostate, adrenal gland and thyroid, and weakest in the hematopoietic tissues bones marrow, lymph node, thymus and spleen.
  • 数据库链接：

    HGNC: 19429

    OMIM: 610801

    KEGG: hsa:254428

    STRING: 9606.ENSP00000356105

    UniGene: Hs.20274