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SLC39A4 Antibody

  • 货号：
    CSB-PA021633GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q6P5W5
  • 基因名：
    SLC39A4
  • 别名：
    SLC39A4; ZIP4; Zinc transporter ZIP4; Solute carrier family 39 member 4; Zrt- and Irt-like protein 4; ZIP-4
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Human SLC39A4
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to zinc availability.
  • 基因功能参考文献：
    1. Results showed decreased expression of Zn uptake transporters ZIP2 and ZIP4 on mRNA and protein level correlating with SHANK3 expression levels, and found reduced levels of ZIP4 protein co-localizing with SHANK3 at the plasma membrane. ZIP4 exists in a complex with SHANK3. Further results confirmed a link between enterocytic SHANK3, ZIP2 and ZIP4. PMID: 28345660
    2. Expression of zinc transporters ZIP4, ZIP14 and ZnT9 in hepatic carcinogenesis-An immunohistochemical study PMID: 29895370
    3. exosomal ZIP4 promotes cancer growth and is a novel diagnostic biomarker for pancreatic cancer. PMID: 30007115
    4. Structural insights of ZIP4 extracellular domain critical for optimal zinc transport have been uncovered. PMID: 27321477
    5. ZIP4 regulates human epidermal homeostasis in patients with acrodermatitis enteropathica. PMID: 27940220
    6. ZIP4 and intracellular zinc have essential roles in tumoral growth in oral squamous cell carcinoma PMID: 28017725
    7. Case Report: heterozygote mutation in SLC39A4 resulting in acrodermatitis enteropathica. PMID: 26351177
    8. Data sho that silencing of zinc transporter ZIP4 resulted in increased bone tissue mineral density, and restoration of bone strength. PMID: 26305676
    9. Studied the zinc binding properties of the large intracellular loop of hZIP4. PMID: 25882556
    10. The results described a previously uncharacterized role of ZIP4 in apoptosis resistance and elucidated a novel pathway through which ZIP4 regulates pancreatic cancer growth. PMID: 24553114
    11. In glioma tumors, high ZIP4 expression was significantly associated with higher grade. PMID: 25921144
    12. Developed is a structural model of ZIP4 by combining protein prediction methods with in situ experiments. Insight into the permeation pathway of ZIP4 is provided. PMID: 25971965
    13. SLC39A4 mutations have roles in zinc deficiency PMID: 25391167
    14. Both acrodermatitis mutations cause absence of the ZIP4 transporter cell surface expression and nearly absent zinc uptake. PMID: 24586184
    15. ZIP4 activates the zinc-dependent transcription factor CREB and requires this transcription factor to increase miR-373 expression through the regulation of its promoter. PMID: 23857777
    16. High ZIP4 expression is associated with glioma. PMID: 23595627
    17. resulkts indicate ZIP4 is the only zinc transporter that is significantly up-regulated in pancreatic cancer and might be the major zinc transporter that plays an important role in pancreatic cancer growth PMID: 23331012
    18. The results suggest that ZIP4 may be a tumor suppressor gene and down-regulation of ZIP4 may be a critical early event in the development of prostate carcinoma PMID: 21803616
    19. Expression of two Zn(2+) influx transporters, ZIP2 and ZIP4, is reduced as a function of retinal pigment epithelium age. PMID: 21603979
    20. Zinc, copper(II), and nickel can be transported by human ZIP4 when the cation concentration is in the micromolar range; nickel can bind to but is not transported by human ZIP4. PMID: 22242765
    21. The transporter ZIP4 is expressed along the entire gastrointestinal tract and acts as a major processor of dietary zinc PMID: 21462106
    22. GSPE and EGCG enhance the expression of cellular zinc importers ZIP4 (SLC39A4). PMID: 20471814
    23. Cell migration assays revealed that RNAi knockdown of Zip4 in Hepa cells depressed in vitro migration whereas forced over-expression in Hepa cells and MCF-7 cells enhanced in vitro migration PMID: 20957146
    24. Zinc can regulate the mRNA expression of ZIP4 in Caco2 cells. PMID: 16986515
    25. Overexpression of ZIP4 caused significantly increased expression of NRP-1, VEGF, MMP-2 and MMP-9 and is associated with angiogenesis, invasion and metastasis pathways in pancreatic cancer. PMID: 20023433
    26. ZIP4 overexpression causes increased IL-6 transcription through CREB, which in turn activates STAT3 and leads to increased cyclin D1 expression PMID: 20160059
    27. A novel member of a zinc transporter family, hZIP4, is defective in acrodermatitis enteropathica. PMID: 12032886
    28. SLC39A4 is centrally involved in the pathogenesis of acrodermatitis enteropathica. PMID: 12068297
    29. Three novel mutations, 1017ins53, which creates premature termination codon, and two mis-sense mutations, R95C and Q303H. PMID: 12787121
    30. temporal and spatial patterns of expression of the mouse ZIP1, 3, 4, and 5 genes in the developing intestine and the effects of maternal dietary zinc deficiency on these patterns of expression were examined PMID: 16682017
    31. ubiquitin-mediated degradation of the ZIP4 protein is critical for regulating zinc homeostasis in response to the upper tier of physiological zinc concentrations. PMID: 17202136
    32. therapeutic strategy whereby ZIP4 is targeted to control pancreatic cancer growth PMID: 18003899
    33. Acrodermatitis enteropathica is a rare autosomal recessive disorder caused by mutations in SLC39A4, which encodes the tissue-specific zinc transporter ZIP4. PMID: 18328205
    34. the clinical manifestations in three acrodermatitis enteropathica patients with a novel mutation PMID: 19416242
    35. results suggest that exon 9 in the SLC39A4 gene encompassing c.1438G should be screened first in the molecular diagnosis of Japanese patients with Acrodermatitis Enteropathic. PMID: 19416256
    36. Knocking down ZIP4 by short hairpin RNA might be a novel treatment strategy for pancreatic cancers with ZIP4 overexpression. PMID: 19755388

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  • 相关疾病：
    Acrodermatitis enteropathica, zinc-deficiency type (AEZ)
  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Note=Colocalized with TFRC in the recycling endosomes. Cycles between endosomal compartments and the plasma membrane in response to zinc availability.
  • 蛋白家族：
    ZIP transporter (TC 2.A.5) family
  • 组织特异性：
    Highly expressed in kidney, small intestine, stomach, colon, jejunum and duodenum.
  • 数据库链接：

    HGNC: 17129

    OMIM: 201100

    KEGG: hsa:55630

    STRING: 9606.ENSP00000301305

    UniGene: Hs.521934