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SLC39A2 Antibody

  • 货号：
    CSB-PA009071
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q9NP94
  • 基因名：
    SLC39A2
  • 别名：
    hZIP2 antibody; 6A1 antibody; Eti-1 antibody; Eti1 antibody; hZIP2 antibody; MGC119190 antibody; OTTHUMP00000164402 antibody; S39A2_HUMAN antibody; SLC39A2 antibody; Solute carrier family 39 (zinc transporter) member 2 antibody; Solute carrier family 39 member 2 antibody; Zinc transporter ZIP2 antibody; ZIP 2 antibody; ZIP-2 antibody; ZIP2 antibody; Zrt and Irt like protein 2 antibody; Zrt- and Irt-like protein 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human ZIP2.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Mediates zinc uptake. Zinc uptake may be mediated by a Zn(2+)-HCO(3)(-) symport mechanism and can function in the presence of albumin. May also transport other divalent cations. May be important in contact inhibition of normal epithelial cells and loss of its expression may play a role in tumorigenesis.
  • 基因功能参考文献：
    1. Results showed decreased expression of Zn uptake transporters ZIP2 and ZIP4 on mRNA and protein level correlating with SHANK3 expression levels, and found reduced levels of ZIP4 protein co-localizing with SHANK3 at the plasma membrane. ZIP4 exists in a complex with SHANK3. Further results confirmed a link between enterocytic SHANK3, ZIP2 and ZIP4. PMID: 28345660
    2. the splice switch to DeltaC-ZIP2 as well as decreased expression of other ZIPs caused zinc deficiency, which is sufficient for induction of MUC5AC. PMID: 29289532
    3. ZIP2 Gln/Arg/Leu polymorphism involve in proinflammatory mediation and zinc homeostasis in elderly population with a more pronounced anti-inflammatory effect of zinc supplementation in subjects carrying ZIP2 Leu- (Arg43Arg) genotype PMID: 26643924
    4. results of this study suggest that ZIP2, a zinc transporter expressed specifically in the epidermis, and zinc taken up by ZIP2 are necessary for the differentiation of keratinocytes PMID: 24936057
    5. Increased expression of Zip2 gene is closely associated with immunity of pulmonary tuberculosis patients, suggesting that the Zip2 gene may play a key role in initial infection control. PMID: 23686108
    6. Expression of two Zn2+ influx transporters, ZIP2 and ZIP4, is reduced as a function of retinal pigment epithelium age. PMID: 21603979
    7. regulation of ZIP2 protein in human breast cancer xenografts PMID: 17786585
    8. Zip2 Gln/Arg/Leu polymorphism plays a role in the susceptibility to carotid artery disease. PMID: 18328005

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    ZIP transporter (TC 2.A.5) family
  • 组织特异性：
    Expressed only in prostate and uterine epithelial cells.
  • 数据库链接：

    HGNC: 17127

    OMIM: 612166

    KEGG: hsa:29986

    STRING: 9606.ENSP00000298681

    UniGene: Hs.175783