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SLC34A1 Antibody

  • 货号：
    CSB-PA733714DSR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA733714DSR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SLC34A1 Polyclonal antibody
  • Uniprot No.：
    Q06495
  • 基因名：
    SLC34A1
  • 别名：
    SLC34A1 antibody; NPT2 antibody; SLC17A2 antibody; Sodium-dependent phosphate transport protein 2A antibody; Sodium-phosphate transport protein 2A antibody; Na(+)-dependent phosphate cotransporter 2A antibody; NaPi-3 antibody; Sodium/phosphate cotransporter 2A antibody; Na(+)/Pi cotransporter 2A antibody; NaPi-2a antibody; Solute carrier family 34 member 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Sodium-dependent phosphate transport protein 2A protein (1-103AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx.
  • 基因功能参考文献：
    1. Our findings show that dysfunction of the human NaPiIIa causes severe renal calcification that may eventually lead to reduced kidney function, rather than complications of phosphate loss PMID: 27378183
    2. Our findings expand the phenotypic spectrum of NaPi-IIa disruption, reinforce its link with proximal tubular impairment, enable longitudinal study of the natural history of the disease PMID: 29029121
    3. Biallelic mutations in CYP24A1 or SLC34A1 were associated with infantile idiopathic hypercalcemia with vitamin D hypersensitivity PMID: 28470390
    4. The identification of autosomal-recessive SLC34A1 mutations in infants with idiopathic infantile hypercalcemia now demonstrates a crucial role of renal sodium-phosphate cotransporter 2A for calcium metabolism as well as phosphate balance in humans PMID: 26047794
    5. Estrogen downregulated NaPi-IIa only in U20S cells expressing both ERalpha and ERbeta, but not in cells expressing either receptor alone. PMID: 25608964
    6. A novel homozygous mutation in the gene encoding the renal sodium-dependent phosphate transporter SLC34A1 was identified in two siblings with hypercalcemia, hypercalciuria, hypophosphatemia, low parathyroid hormone (PTH), and nephrocalcinosis. PMID: 25050900
    7. B-RAF increases the cell surface protein abundance and activity of the type II Na+-coupled phosphate transporters NaPi-IIa and NaPi-IIb. PMID: 24258620
    8. JAK2 contributes to the regulation of phosphate transporter NaPiIIa PMID: 23313484
    9. Results indicate that the PDZ1 domain is critical for NHERF1-NPT2a interaction in humans and for the control of NPT2a expression at the plasma membrane. PMID: 22506049
    10. Our cases suggest a contiguous gene deletion syndrome including NSD1 and SLC34A1 and provide a potential genetic basis for idiopathic infantile hypercalcemia. PMID: 21597970
    11. Results suggest that a 31-kDa nuclear protein from kidney-derived cells binds to the C/EBP-like region of the type II Na/Pi-cotransporter promoter. PMID: 9683733
    12. These findings show that disruption of the human NaPi-IIa profoundly impairs overall renal phosphate reabsorption and proximal-tubule function and provide evidence of the critical role of NaPi-IIa in human renal phosphate handling. PMID: 20335586
    13. type IIc is a growth-related renal Na/P(i) cotransporter, which has a high affinity for P(i) and is electroneutral PMID: 11880379
    14. mutations in the NPT2 gene may contribute to nephrocalcinosis in a subset of patients with familial hypercalciuria PMID: 12674325
    15. In Xenopus oocyte expression experiments P(i)-induced currents were reduced in mutants, whereas P(i) and Na affinities and other transport characteristics were not affected PMID: 14672348
    16. Taken together, these findings suggest that ECL-1 and ECL-4 may not directly form part of the transport pathway, but specific sites in these linkers can interact directly or indirectly with parts of NaPi-IIa. PMID: 15504898
    17. The results allowed us to modify previous models for the transport cycle of NaPi-II transporters by including voltage dependency of HPO4(2-) binding and proton modulation of the first Na+ binding step. PMID: 15613617
    18. compartmentalization may play an important role in the down-regulation of NaPi-IIa via endocytosis PMID: 16105044
    19. Although genetic variants of NPT2a are not rare, they do not seem to be associated with clinically significant renal phosphate or calcium handling anomalies in a large cohort of hypercalciuric stone-forming pedigrees PMID: 16688119
    20. Therefore, understanding the mechanisms that control the apical expression of NaPi-IIa and NaPi-IIc as well as their functional properties is critical to understanding how an organism achieves P i homeostasis. PMID: 16955105

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  • 相关疾病：
    Nephrolithiasis/osteoporosis, hypophosphatemic, 1 (NPHLOP1); Fanconi renotubular syndrome 2 (FRTS2); Hypercalcemia, infantile, 2 (HCINF2)
  • 亚细胞定位：
    Apical cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    SLC34A transporter family
  • 组织特异性：
    Kidney and lung.
  • 数据库链接：

    HGNC: 11019

    OMIM: 182309

    KEGG: hsa:6569

    STRING: 9606.ENSP00000321424

    UniGene: Hs.936