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SLC30A1 Antibody

  • 货号：
    CSB-PA733704ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: SLC30A1 antibody at 3.75μg/ml
      Lane 1: A549 whole cell lysate
      Lane 2: HepG2 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 55 kDa
      Observed band size: 55 kDa
    • Immunohistochemistry of paraffin-embedded human endometrial cancer using CSB-PA733704ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SLC30A1 Polyclonal antibody
  • Uniprot No.：
    Q9Y6M5
  • 基因名：
    SLC30A1
  • 别名：
    SLC30 A1 antibody; SLC30A 1 antibody; SLC30A1 antibody; Solute carrier family 30 (zinc transporter), member 1 antibody; Solute carrier family 30 (zinc transporter), member1 antibody; Solute carrier family 30 member 1 antibody; Solute carrier family 30, member 1 antibody; Zinc transporter 1 antibody; Zinc transporter1 antibody; ZNT 1 antibody; ZnT-1 antibody; ZNT1_HUMAN antibody; ZRC 1 antibody; ZRC1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Zinc transporter 1 protein (328-507AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May be involved in zinc transport out of the cell.
  • 基因功能参考文献：
    1. This study showed that there was a significant increase in protein levels of ZnT1 in the prefrontal cortex in Major depressive disorder, relative to control subjects PMID: 27661418
    2. MTF1 heads a hierarchy of zinc sensors, and through controlling the expression of a raft of metallothioneins and other key proteins involved in controlling intracellular zinc levels (e.g. ZnT1) alters zinc buffering capacity and total cellular zinc content. PMID: 26824222
    3. Data indicate that zinc transporters ZnT1 and Zip1 were the most abundantly expressed zinc transporters in leukocytes. PMID: 24488210
    4. ZnT-1 extrudes zinc from mammalian cells by functioning as a Zn(2+)/H(+) exchanger. PMID: 24951051
    5. Data indicate that the expression levels of ZnT and ZIP families in the three cell lines, when treated with high concentration of ZnSO4, increased and decreased corresponding to their functions, respectively. PMID: 23839533
    6. ZnT-1 augments CaV3.1 and CaV3.2 channel signals by stimulating the Ras-ERK pathways. PMID: 22572848
    7. The results of this study showed that signi fi cant positive correlations between ZIP1,ZnT1, and ZnT6 in most brain in patient with Alzheimer's disease. PMID: 22349685
    8. The metallothionein gene had a higher expression in the blood, when compared to zinc transporters ZnT-1, Zip-1, and Zip-3 (p=0.01 in obese patients. PMID: 21053094
    9. Differentiated Caco-2 cells tolerate significantly higher levels of zinc compared to undifferentiated Caco-2 cells, which was accompanied by upregulated ZnT-1 and downregulated ZIP1 levels. PMID: 21103883
    10. the transporter ZnT1 at the basolateral membrane, regulate the amount of zinc released to the portal circulation for systemic distribution PMID: 21462106
    11. GSPE and EGCG inhibit the expression of zinc-binding metallothioneins and plasma membrane zinc exporter ZnT1 (SLC30A1). PMID: 20471814
    12. our results suggest that alterations in Zn transport proteins ZnT-1, ZnT-4 and ZnT-6 may contribute to the pathology observed in preclinical Alzheimer's disease subjects before onset of clinical symptoms PMID: 19371353
    13. The effects of zinc and cadmium on the expression and membrane localization of metallothioneins and ZNT1 in hepatoma cells are reproted. PMID: 19900532
    14. ZnT-1 expression was found to be augmented in the atria of atrial tachycardia patients. PMID: 20201890
    15. AIDL cells exhibited a lower expression of zinc transporter 1 (ZnT1) and higher expression of ZnT3 than LNCaP cells. PMID: 14662799
    16. Our findings therefore indicate that ZnT-1 modulates the permeation of cations through LTCC, thereby, regulating cation homeostasis through this pathway. PMID: 15451416
    17. correlation analysis of ZnT-1 levels and senile plaque and neurofibrillary tangle counts of Alzheimer's disease showed a significant positive correlation PMID: 16179263
    18. regulation of ZnT-1 protein in human breast cancer xenografts PMID: 17786585
    19. This study provides evidence for increased ZnT-1 expression in atria of patients with atrial fibrillation. PMID: 17971132
    20. hZnT-1 is the most regulated zinc exporter in leukocytes. it i sfound in the plasma membrane. PMID: 17971500
    21. HPV16 E5 protein binds to EVER and ZnT-1 and blocks their negative regulation PMID: 18158319
    22. Data show that ZNT1 is extensively present in the Abeta-positive plaques in the cortex of human AD brains. PMID: 18639746
    23. zinc transporter 1 is an endogenous inhibitor of L-type calcium channels PMID: 19767393

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family, SLC30A subfamily
  • 数据库链接：

    HGNC: 11012

    OMIM: 609521

    KEGG: hsa:7779

    STRING: 9606.ENSP00000355968

    UniGene: Hs.519469