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SLC27A2 Antibody

  • 货号：
    CSB-PA021534GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O14975
  • 基因名：
  • 别名：
    ACSVL1 antibody; FACVL1 antibody; FATP 2 antibody; FATP-2 antibody; FATP2 antibody; Fatty acid coenzyme A ligase, very long chain 1 antibody; Fatty acid transport protein 2 antibody; Fatty-acid-coenzyme A ligase antibody; hFACVL1 antibody; HsT17226 antibody; Long chain fatty acid CoA ligase antibody; Long-chain-fatty-acid--CoA ligase antibody; S27A2_HUMAN antibody; Slc27a2 antibody; Solute carrier family 27 (fatty acid transporter), member 2 antibody; Solute carrier family 27 member 2 antibody; THCA CoA ligase antibody; THCA-CoA ligase antibody; Very long chain acyl CoA synthetase antibody; Very long chain fatty acid CoA ligase antibody; Very long chain fatty acid coenzyme A ligase 1 antibody; very long-chain 1 antibody; Very long-chain acyl-CoA synthetase antibody; Very long-chain-fatty-acid-CoA ligase antibody; VLACS antibody; VLCS antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human SLC27A2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acyl CoA synthetase that activates long-chain and very long-chain fatty acids (VLCFAs) by catalyzing the formation of fatty acyl-CoA. Can also activate branched-chain fatty acids such as phytanic acid and pristanic acid. Does not activate C24 bile acids, cholate and chenodeoxycholate. In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Exhibits long-chain fatty acids (LCFA) transport activity and plays an important role in hepatic fatty acid uptake.; Exhibits both long-chain fatty acids (LCFA) transport activity and acyl CoA synthetase towards very long-chain fatty acids. Shows a preference for generating CoA derivatives of n-3 fatty acids, which are preferentially trafficked into phosphatidylinositol.; Exhibits long-chain fatty acids (LCFA) transport activity but lacks acyl CoA synthetase towards very long-chain fatty acids.
  • 基因功能参考文献：
    1. In overweight/obese pregnancies, the increased FATP2 placental expression could contribute to increased fatty acid delivery to the fetus. PMID: 27016784
    2. In mice Grassofermata decreased absorption of (13)C-oleate demonstrating its potential as a therapeutic agent. PMID: 26284975
    3. Protective effects of breastfeeding are reflected in higher expression levels of SLC27A2, FASN, PPARalpha and INSR in blood cells. PMID: 24277691
    4. these data support the conclusion that FATP2 has a dual function in the pathways linking the transport and activation of exogenous fatty acids. PMID: 24113382
    5. FATP2a functions in fatty acid transport and activation and provides specificity toward n-3 fatty acids in which the corresponding n-3 acyl-CoAs are preferentially trafficked into acyl-CoA pools destined for phosphatidylinositol incorporation PMID: 21768100

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein. Peroxisome membrane; Peripheral membrane protein. Cell membrane; Multi-pass membrane protein. Microsome.
  • 蛋白家族：
    ATP-dependent AMP-binding enzyme family
  • 组织特异性：
    Expressed in liver, kidney, placenta and pancreas.
  • 数据库链接：

    HGNC: 10996

    OMIM: 603247

    KEGG: hsa:11001

    STRING: 9606.ENSP00000267842

    UniGene: Hs.11729