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SLC24A1 Antibody

  • 货号：
    CSB-PA070252
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    O60721
  • 基因名：
    SLC24A1
  • 别名：
    CSNB1D antibody; HsT17412 antibody; KIAA0702 antibody; Na(+)/K(+)/Ca(2+) exchange protein 1 antibody; Na(+)/K(+)/Ca(2+)-exchange protein 1 antibody; NCKX antibody; NCKX1 antibody; NCKX1_HUMAN antibody; Retinal rod Na Ca+K exchanger antibody; Retinal rod Na+/Ca+/K+ exchanger antibody; Retinal rod Na-Ca+K exchanger antibody; RODX antibody; Slc24a1 antibody; Sodium/potassium/calcium exchanger 1 antibody; Solute carrier family 24 (sodium/potassium/calcium exchanger) member 1 antibody; Solute carrier family 24 member 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human NCKX1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+).
  • 基因功能参考文献：
    1. We report the association of many previously unreported variants with retinal disease, as well as new disease phenotypes associated with known genes, including the first association of the SLC24A1 gene with retinitis pigmentosa PMID: 27624628
    2. The index patient and his affected brother carry a homozygous single-nucleotide variants (SNVs) in sodium-calcium, potassium exchanger (SLC24A1) (c.2401G > T). PMID: 26822852
    3. A mutation in SLC24A1 is implicated in autosomal-recessive congenital stationary night blindness. PMID: 20850105
  • 相关疾病：
    Night blindness, congenital stationary, 1D (CSNB1D)
  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family, SLC24A subfamily
  • 组织特异性：
    Expressed in the retina, particularly in the inner segment, outer and inner nuclear layers, and ganglion cell layer.
  • 数据库链接：

    HGNC: 10975

    OMIM: 603617

    KEGG: hsa:9187

    STRING: 9606.ENSP00000261892

    UniGene: Hs.173092