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SLC23A1 Antibody

  • 货号：
    CSB-PA887038LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: SLC23A1 antibody at 3μg/ml
      Lane 1: A549 whole cell lysate
      Lane 2: Mouse liver tissue
      Lane 3: Mouse kidney tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 65, 66, 29 kDa
      Observed band size: 65 kDa
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA887038LA01HU at dilution of 1:100
    • Immunofluorescent analysis of A549 cells using CSB-PA887038LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
    • Western Blot
      Positive WB detected in: A549 whole cell lysate, L02 whole cell lysate, HepG2 whole cell lysate, Hela whole cell lysate, SH-SY5Y whole cell lysate, K562 whole cell lysate, Mouse liver tissue
      All lanes: SLC23A1 antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 65, 66, 29 kDa
      Observed band size: 80 kDa
  • 其他：

产品详情

  • 产品描述：

    CUSABIO uses a partial recombinant protein mapping within 173-259 amino acids of the human SLC23A1 protein to immunize the rabbit to produce the anti-SLC23A1 polyclonal antibody. This SLC23A1 antibody exists as the unconjugated IgG isoform. The purity of this antibody is 95%+ using protein G affinity chromatography.

    This SLC23A1 antibody shows reactivity to human and mouse samples. And it has been validated for use in ELISA, WB, IHC, and IF applications. Its target protein SLC23A1 plays a crucial role in the absorption, reabsorption, and recycling of vitamin C.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SLC23A1 Polyclonal antibody
  • Uniprot No.：
    Q9UHI7
  • 基因名：
    SLC23A1
  • 别名：
    hSVCT1 antibody; Na(+)/L-ascorbic acid transporter 1 antibody; S23A1_HUMAN antibody; Slc23a1 antibody; Sodium-dependent vitamin C transporter 1 antibody; solute carrier family 23 (nucleobase transporters); member 1 antibody; Solute carrier family 23 member 1 antibody; SVCT1 antibody; Yolk sac permease-like molecule 3 antibody; YSPL3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Solute carrier family 23 member 1 protein (173-259AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SLC23A1 Antibody (CSB-PA887038LA01HU)，的标记方式是Non-conjugated。对于SLC23A1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA887038LB01HU SLC23A1 Antibody, HRP conjugated ELISA
    FITC CSB-PA887038LC01HU SLC23A1 Antibody, FITC conjugated
    Biotin CSB-PA887038LD01HU SLC23A1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate.
  • 基因功能参考文献：
    1. consensus site for HNF1 that is crucial for the regulation of the human SVCT1 promoter is present in the SVCT1 rat promoter but has no effect on its transcriptional activity PMID: 25933589
    2. SNP rs6596473 of SLC23A1 is suggested to be associated with AgP. results add to previous reports vitamin C plays a role in pathogenesis of periodontitis. PMID: 24708273
    3. Data from observational/genetic association studies in Europe suggest an SNP in SLC23A1 (rs33972313) is associated with up-regulation of circulating L-ascorbic acid but not with any cardiometabolic/cardiovascular outcome investigated. [META-ANALYSIS] PMID: 25527764
    4. The SVCT1 was induced and localized to the apical membrane of tubular epithelial cells. PMID: 22990596
    5. A genetic variant in the SLC23A1 ascorbate transporter locus was identified and is associated with an increased risk of Crohn disease in a white Canadian inflammatory bowel diseases cohort. PMID: 24284447
    6. SVCT1 directly interacts with GRHPR. PMID: 23599041
    7. These findings show a role for Rab8a in the physiological function of SVCT1 in intestinal epithelia. PMID: 23014846
    8. A genetic variant (rs33972313) in the SLC23A1 vitamin C active transporter locus was identified that is reliably associated with circulating concentrations of L-ascorbic acid in the general population. PMID: 20519558
    9. Observational study and meta-analysis of gene-disease association. (HuGE Navigator) PMID: 20519558
    10. SVCT1 is the transporter that allows vectorial uptake of ascorbic acid in differentiated CaCo-2 cells PMID: 12381735
    11. Results provide the first direct resolution of functional hSVCT1 expression at the apical cell surface of polarized epithelia and define an apical targeting signal of relevance to transporters of diverse substrate specificity. PMID: 15084584
    12. Findings link genetic variants in the vitamin C transporter gene SLC23A1 to spontaneous preterm birth. PMID: 16357110
    13. C uptake is increased in UVB-irradiated keratinocytes through the translocation of SVCT-1 and regulates inflammatory response in the skin via the downregulation of IL-8 and MCP-1 production PMID: 17008880
    14. We present a transport model for SVCT1 that will provide a framework for investigating the impact of specific mutations and polymorphisms in SLC23A1 and help us better understand the contribution of SVCT1 to vitamin C metabolism in health and disease. PMID: 18094143
    15. The results suggest that uncharged His51 of hSVCT1, directly or indirectly, contributes to substrate binding through the hydrogen bond. PMID: 18247577
    16. SVCT1 may be targeted to facilitate the delivery of drugs with low bioavailability by conjugating with ascorbic acid PMID: 18417304
    17. N-Glycosylation is therefore essential for SVCT1 functionality. PMID: 18619416
    18. The analysis of common single nucleotide polymorphisms in SLC23A1 revealed no association with colorectal adenoma risk. PMID: 18791929
    19. Results using short interfering RNA suggest that in HepG2 cells, decreasing hSVCT2 message levels reduces the overall ascorbic acid uptake process more than decreasing hSVCT1 message levels. PMID: 18845575
    20. Results describe the membrane topology of human SVCT1 and SVCT2, and the role of glycosylation on protein transport. PMID: 19379732
    21. HNF-1alpha and/or HNF-1beta binding is required for SVCT1 expression PMID: 19741195
    22. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 18818748

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Xanthine/uracil permease family, Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily
  • 组织特异性：
    Highly expressed in adult small intestine, kidney, thymus, ovary, colon, prostate and liver, and in fetal kidney, liver and thymus.
  • 数据库链接：

    HGNC: 10974

    OMIM: 603790

    KEGG: hsa:9963

    STRING: 9606.ENSP00000302851

    UniGene: Hs.643467