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SLC22A9 Antibody

  • 货号：
    CSB-PA811607LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA811607LA01HU at dilution of 1:100
    • Immunofluorescent analysis of A431 cells using CSB-PA811607LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SLC22A9 Polyclonal antibody
  • Uniprot No.：
    Q8IVM8
  • 基因名：
    SLC22A9
  • 别名：
    SLC22A9 antibody; hOAT4 antibody; OAT7 antibody; UST3 antibody; Solute carrier family 22 member 9 antibody; Organic anion transporter 7 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Solute carrier family 22 member 9 protein (45-143AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SLC22A9 Antibody (CSB-PA811607LA01HU)，的标记方式是Non-conjugated。对于SLC22A9 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA811607LB01HU SLC22A9 Antibody, HRP conjugated ELISA
    FITC CSB-PA811607LC01HU SLC22A9 Antibody, FITC conjugated
    Biotin CSB-PA811607LD01HU SLC22A9 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Sodium-independent organic anion transporter which exhibits high specificity for sulfated conjugates of xenobiotics and steroid hormones. It is also specifically activated by 3 to 5 carbons-containing short-chain fatty acids/SCFAs, including propionate, butyrate and valerate. May operate the exchange of sulfated organic components against short-chain fatty acids/SCFAs at the sinusoidal membrane of hepatocytes.
  • 基因功能参考文献：
    1. two human organic anion transporters OAT2 and OAT7 activities were assessed. PMID: 28945155
    2. Pravastatin is the first identified OAT7 drug substrate. Substantial inter-individual variability in hepatic OAT7 expression, majorly driven by HNF4alpha, may contribute to pravastatin drug disposition and might affect response. PMID: 26239079
    3. uptake of steroid sulfates by isolated trophoblasts is mediated by OATP-B and OAT-4 suggesting a physiological role of both carrier proteins in placental uptake of fetal-derived steroid sulfates. PMID: 12409283
    4. Both progesterone and activation of PKC inhibited hOAT4 activity through redistribution of the transporter from cell surface to the intracellular compartments. PMID: 17341544
    5. OAT7 is the first liver-specific transporter among members of the organic anion transporters of SLC22 family. PMID: 17393504
    6. The data provide a model for the concerted action of OAT1 mediating apical secretion of glutarate derivatives from proximal tubule cells PMID: 18365245
    7. The regulatory single nucleotide polymorphism (SNP) of OAT4 found in the promoter region of nephrectomized patients is unlikely to influence mRNA expression or promoter activity of OAT4. PMID: 18414781
    8. Review summarizes current knowledge on the functional and phenotypic consequences of genetic variation in intestinally, hepatically and renally expressed members of solute carrier family (SLC22) member 9. PMID: 18466105
    9. Functional differences in steroid uptake of SLC22A9 and SLC02B1 in human placenta are reported. PMID: 18501590
    10. Human organic anion transporter hOAT4 is a transporter of perfluorooctanoic acid. PMID: 19371258

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  • 亚细胞定位：
    Basolateral cell membrane; Multi-pass membrane protein. Note=Enriched at the sinusoidal part of the plasma membrane.
  • 蛋白家族：
    Major facilitator (TC 2.A.1) superfamily, Organic cation transporter (TC 2.A.1.19) family
  • 组织特异性：
    Specifically expressed in liver by hepatocytes (at protein level).
  • 数据库链接：

    HGNC: 16261

    OMIM: 607579

    KEGG: hsa:114571

    STRING: 9606.ENSP00000279178

    UniGene: Hs.502772