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SLC22A11 Antibody

  • 货号：
    CSB-PA882097ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA882097ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA882097ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SLC22A11 Polyclonal antibody
  • Uniprot No.：
    Q9NSA0
  • 基因名：
    SLC22A11
  • 别名：
    hOAT4 antibody; MGC34282 antibody; OAT4 antibody; Organic anion transporter 4 antibody; S22AB_HUMAN antibody; SLC22A11 antibody; Solute carrier family 22 (organic anion/urate transporter) member 11 antibody; Solute carrier family 22 member 11 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Solute carrier family 22 member 11 protein (40-150AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Mediates saturable uptake of estrone sulfate, dehydroepiandrosterone sulfate and related compounds.
  • 基因功能参考文献：
    1. The first genome-wide association study for serum uric acid level in Indians revealed association of SLC2A9, SLC22A11 and ABCG2 gene variants at genome wide significance level in Type 2 diabetes patients. PMID: 26902266
    2. modifies placental passage of perfluorinated alkyl acids, may decrease fetal exposure PMID: 26303760
    3. The regulation of hOAT4 activity was mediated by sgk2 acting through Nedd4-2. PMID: 26740304
    4. SLC22A11 at the basal plasma membrane of human placental syncytiotrophoblasts plays a predominant role in the uptake of 16alpha-OH DHEAS for placental estriol synthesis. PMID: 25919187
    5. A common variant of OAT4/SLC22A11 is associated with renal underexcretion type gout in Japanese men. PMID: 24025986
    6. Our analysis provides evidence for multiple ancestral-specific effects across the SLC22A11/SLC22A12 locus that presumably influence the activity of OAT4 and URAT1 and risk of gout. PMID: 24360580
    7. When investigating the genes separately, SLC22A11 and SLC2A9 showed a significant interaction, consistent with the former encoding an organic anion/dicarboxylate exchanger, which mediates diuretic transport in the kidney. PMID: 22753387
    8. Genetic variants of human organic anion transporter 4 demonstrate altered transport of endogenous substrates. PMID: 20668102
    9. The down-regulation of hOAT4 activity by activation of protein kinase C and the up-regulation of hOAT4 activity by NHERF-1 are mediated through alteration of hOAT4 internalization. PMID: 20140636
    10. Several naturally occurring SNPs encode variant hOAT4s that may impair the renal tubular re-absorption of important drug substrates. PMID: 20015291
    11. elucidation of the molecular mechanism for renal tetracycline transport by human organic anion transporters (hOATs) using proximal tubular cells stably expressing hOATs PMID: 11855680
    12. Glycosylation serves as a means to specifically regulate hOAT4 function in vivo. PMID: 15576633
    13. hOAT4 is the long-postulated, low-affinity apical urate anion exchanger that facilitates hydrochlorothiazide-associated hyperuricemia. PMID: 17229912
    14. The interaction of PDZ proteins with hOAT4 may be cell-specific. In placenta, a different set of interacting proteins from PDZK1 and NHERF1 may be required to modulate hOAT4 activity. PMID: 17602283
    15. The present study demonstrates that hOAT4 variants can causing inter-individual variation in anionic drug uptake and, therefore, could be used as markers for certain diseases including osteoporosis. PMID: 18414001
    16. Findings suggest that hOAT4 and caveolin-1 share a cellular expression in the plasma membrane and caveolin-1 up-regulates the organic anionic compound uptake by hOAT4 under the normal physiological condition. PMID: 18985008

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Major facilitator (TC 2.A.1) superfamily, Organic cation transporter (TC 2.A.1.19) family
  • 组织特异性：
    Detected in placenta and kidney.
  • 数据库链接：

    HGNC: 18120

    OMIM: 607097

    KEGG: hsa:55867

    STRING: 9606.ENSP00000301891

    UniGene: Hs.220844