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SLC18A1 Antibody

  • 货号：
    CSB-PA021426LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Mouse liver tissue
      All lanes: SLC18A1 antibody at 2.7μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 57, 51, 53 kDa
      Observed band size: 57 kDa
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA021426LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SLC18A1 Polyclonal antibody
  • Uniprot No.：
    P54219
  • 基因名：
  • 别名：
    4832416I10Rik antibody; Adrenal chromaffin granule amine transporter, CGAT antibody; CGAT antibody; Chromaffin granule amine transporter antibody; MGC28683 antibody; MGC37299 antibody; SLC18A1 antibody; Solute carrier family 18 (vesicular monoamine), member 1 antibody; Solute carrier family 18 member 1 antibody; VAT 1 antibody; VAT1 antibody; Vesicular amine transporter 1 antibody; VMAT 1 antibody; VMAT1_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Chromaffin granule amine transporter protein (66-120AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SLC18A1 Antibody (CSB-PA021426LA01HU)，的标记方式是Non-conjugated。对于SLC18A1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA021426LB01HU SLC18A1 Antibody, HRP conjugated ELISA
    FITC CSB-PA021426LC01HU SLC18A1 Antibody, FITC conjugated
    Biotin CSB-PA021426LD01HU SLC18A1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in the transport of biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles of neuroendocrine and endocrine cells.
  • 基因功能参考文献：
    1. SLC18A1 might complement other biomarkers currently under study in relation to programmed cell death protein 1/programmed cell death protein ligand 1 inhibition PMID: 30194079
    2. Polymorphisms within the SLC18A gene are associated with asthenozoospermia through sperm count and motility. PMID: 29602729
    3. Vmat1 polymorphisms are not associated with suicidal behavior. PMID: 29536333
    4. results contribute to the evidence indicating an association between the VMAT1 gene and structural brain alterations in depression. PMID: 28408293
    5. VMAT1 rs1390938/Thr136Ile is associated with mood, personality, and alcohol use in the general population. Subjects homozygous for the "hyperfunction" allele (AA; Ile/Ile) appear to be more resilient to these disorders. PMID: 26861143
    6. The germline deletions at SLC18A1 contributed to the development of CRC. PMID: 28968818
    7. rs2270641 SNP was associated with ASD risk only in over-dominant model. AA genotype of the rs1390938 was protective against ASD under dominant and recessive models. PMID: 28476685
    8. Genetic variants in VMAT1 contribute to the severity of alcohol withdrawal in patients of European descent. PMID: 26876819
    9. VMAT1 and VMAT2 are expressed in the majority of neuroblastomas PMID: 26338179
    10. SLC18A1 gene polymorphisms are associated with the risk of paranoid schizophrenia in Russians and Tatars. PMID: 25842846
    11. The data of this study showed that VMAT1 polymorphisms influence monoamine signaling, the functional response of emotional brain circuits and risk for psychopathology. PMID: 23337945
    12. Deletion of amino acids 307-338 in hVMAT1 isoform-b abolishes transport activity, and a 136-Thr partially reduces activity of isoform-a. PMID: 23090274
    13. we found a significant down-regulation of the gene coding for the vesicular monoamine transporter (VMAT1)in enteroendocrine cells infected with Chlamydia trachomatis PMID: 21883697
    14. Human bronchial arterial smooth muscle cells express OCT-1 and extraneuronal monoamine transporter(EMT). EMT is the predominant plasma membrane transporter for norepinephrine uptake. PMID: 12807698
    15. Greater expression of VMAT 1 in von Hippel-Lindau syndrome than multiple endocrine neoplasia type 2. Expression of VMAT 2 did not differ significantly. PMID: 16189177
    16. VMAT1Delta15 is not localized in large, dense core vesicles as the native form but in the endoplasmic reticulum. While VMAT1 can take up serotonin, VMAT1Delta15 cannot, indicating different functions for the two forms of VMAT1. PMID: 16326835
    17. Expression analysis confirmed that VMAT1 is expressed in human brain at the mRNA and protein level. Results suggest that variations in the VMAT1 gene may confer susceptibility to Bipolar Disorder in patients of European descent. PMID: 16936705
    18. Our findings support the hypothesis that anxiety-related personality traits are associated with variation in the VMAT1/SLC18A1 gene. PMID: 18249496
    19. Polymorphism in VMAT1 gene on chromosome 8p is associated with schizophrenia. PMID: 18451639

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  • 亚细胞定位：
    [Isoform 1]: Cytoplasmic vesicle membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein.; [Isoform 2]: Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Major facilitator superfamily, Vesicular transporter family
  • 组织特异性：
    Highly expressed in chromaffin cells of the adrenal medulla (at protein level). Detected in peripheral sympathetic ganglia (at protein level). Found in some paracrine cells in stomach and duodenum (at protein level).
  • 数据库链接：

    HGNC: 10934

    OMIM: 193002

    KEGG: hsa:6570

    STRING: 9606.ENSP00000276373

    UniGene: Hs.158322