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SLC17A8 Antibody

  • 货号：
    CSB-PA107772
  • 规格：
    ￥1100
  • 图片：
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human cerebella tissue and Human cerebrum tissue lysates, Primary antibody: CSB-PA107772(SLC17A8 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SLC17A8 Polyclonal antibody
  • Uniprot No.：
    Q8NDX2
  • 基因名：
  • 别名：
    Solute carrier family 17 (vesicular glutamate transporter), member 8; DFNA25; VGLUT3
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of human SLC17A8
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.
  • 基因功能参考文献：
    1. Novel pathogenic splicing mutation in SLC17A8 gene identified in a family with hearing loss. PMID: 28647561
    2. A point mutation in VGLUT3 dramatically reduces its expression in synaptic terminals without altering its function. PMID: 28314816
    3. The results of this study identify VGLUT3 as an unexpected regulator of drug abuse. PMID: 26239290
    4. The results from our study suggest that the p.M206Nfs*4 mutation in the SLC17A8 gene is likely a pathogenic mutation that causes autosomal dominant non-syndromic hearing loss. PMID: 26797701
    5. The absence of VGLUT3 in transgenic mice leads to an up-regulation of the midbrain dopamine system and ameliorates motor dysfunction in a model of Parkinson's disease. PMID: 26558771
    6. human vesicular glutamate transporter 3 was cloned, shows 72% identity to both hVGLUT1 and hVGLUT2, and its expression in brain overlaps with hVGLUT1 and hVGLUT2 PMID: 12151341
    7. Docking and homology modeling explain the inhibition of VGLUT3. PMID: 17660252
    8. VGLUT3 immunoreactivity covered only a limited portion of the possible Glu-ergic pathways in the human fetal small intestine. PMID: 18498073
    9. SLC17A8 encodes vesicular glutamate transporter-3, VGLUT3 and its impairment has a role in nonsyndromic deafness DFNA25 and inner hair cell dysfunction PMID: 18674745

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  • 相关疾病：
    Deafness, autosomal dominant, 25 (DFNA25)
  • 亚细胞定位：
    Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome.
  • 蛋白家族：
    Major facilitator superfamily, Sodium/anion cotransporter family, VGLUT subfamily
  • 组织特异性：
    Expressed in amygdala, cerebellum, hippocampus, medulla, spinal cord and thalamus.
  • 数据库链接：

    HGNC: 20151

    OMIM: 605583

    KEGG: hsa:246213

    STRING: 9606.ENSP00000316909

    UniGene: Hs.116871