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SLC16A7 Antibody

  • 货号：
    CSB-PA021414LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: K-562 whole cell lysate, HepG2 whole cell lysate
      All lanes: SLC16A7 antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 53 kDa
      Observed band size: 53 kDa
    • IHC image of CSB-PA021414LA01HU diluted at 1:200 and staining in paraffin-embedded human ovarian cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
    • Immunofluorescence staining of Hela cells with CSB-PA021414LA01HU at 1:200, counter-stained with DAPI. The cells were blocked in 10% normal Goat Serum and incubated with the antibody overnight at 4°C. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SLC16A7 Polyclonal antibody
  • Uniprot No.：
    O60669
  • 基因名：
    SLC16A7
  • 别名：
    MCT 2 antibody; MCT antibody; Monocarboxylate transporter 2 antibody; MonocarboxylateTransporter 2 antibody; MOT2 antibody; MOT2_HUMAN antibody; SLC16A7 antibody; Solute carrier family 16 (monocarboxylate transporter), member 7 antibody; Solute carrier family 16 member 7 antibody; Solute carrier Family 16 Monocarboxylic Acid Transporters Member 7 antibody; Solute carrier family 16, member 7 (monocarboxylic acid transporter 2) antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Monocarboxylate transporter 2 protein (197-279AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SLC16A7 Antibody (CSB-PA021414LA01HU)，的标记方式是Non-conjugated。对于SLC16A7 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA021414LB01HU SLC16A7 Antibody, HRP conjugated ELISA
    FITC CSB-PA021414LC01HU SLC16A7 Antibody, FITC conjugated
    Biotin CSB-PA021414LD01HU SLC16A7 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Functions as high-affinity pyruvate transporter.
  • 基因功能参考文献：
    1. Adipocytes promote malignant growth of breast tumors with MCT2 expression via beta-hydroxybutyrate. PMID: 28281525
    2. SLC16A7 (MCT2) epigenetic regulation results in protein over-expression, affecting signalling and cellular phenotypes in prostate cancer PMID: 26035357
    3. Data suggest that monocarboxylate transporter 2 (MCT2) at peroxisomes is related to an increase in beta-oxidation levels which may be crucial for malignant transformation. PMID: 25639644
    4. This study identified that CGPs was found to significantly correlate with the differential expression and methylation of genes encoding solute carrier family 16, member 7. PMID: 25243493
    5. Our findings suggest that SNPs in MCT1 and MCT2 genes may affect clinical outcomes and can be used to predict the response to adjuvant chemotherapy in NSCLC patients who received surgical treatment once validated in future study. PMID: 25578492
    6. SNPs in MCT1 and MCT2 genes may affect clinical outcomes and can be used to predict the response to adjuvant chemotherapy in CRC patients who received surgical treatment. PMID: 25492048
    7. MCT2-3' UTR SNP (+2626 G > A) had a strong association with oligoasthenoteratozoospermia. PMID: 24799634
    8. this study provided evidence for the presence of MCT2 in prostate cancer, selectively labeling malignant glands. PMID: 23192371
    9. The monocarboxylate transporter 2 (MCT2) protein was tumor-selectively expressed in human colorectal malignancies and knockdown of MCT2 induces mitochondrial dysfunction, cell-cycle arrest, and senescence. PMID: 22964484
    10. Light microscopic immunohistochemistry revealed significantly less perivascular MCT2 immunoreactivity in the hippocampal formation in medial temporal lobe epilepsy than in non-MTLE patients PMID: 22535546
    11. data suggest that extracellular membrane-bound CAIV, but not cytosolic CAII, augments transport activity of MCT2 in a non-catalytic manner, possibly by facilitating a proton pathway other than His-88 PMID: 21680735
    12. Ocular absorption of monocarboxylic acid drugs may be enhanced by MCT transporter SLC16A7, and the absorption route provided by this transporter may be utilized to improve the bioavailability of topically applied ophthalmic drugs. PMID: 20035863
    13. MCT2 immunoreactivity was noted in astrocytic cell bodies from week 19 and spread subsequently to the astrocyte end-feet in contact with blood vessels of visual cortex. PMID: 14757520
    14. Colorectal neoplasms showed a loss of expression of MCT2 in plasma membranes. PMID: 18188595
    15. These data demonstrate neuronal MCT2 expression in human, but since a portion of it exhibits a distinct synaptic localization, it further supports a putative role for MCT2 in adjustment of energy supply to levels of activity. PMID: 18598673

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Major facilitator superfamily, Monocarboxylate porter (TC 2.A.1.13) family
  • 组织特异性：
    Detected in heart and in blood lymphocytes and monocytes (at protein level). High expression in testis, moderate to low in spleen, heart, kidney, pancreas, skeletal muscle, brain and Leukocyte. Restricted expression in normal tissues, but widely expressed
  • 数据库链接：

    HGNC: 10928

    OMIM: 603654

    KEGG: hsa:9194

    STRING: 9606.ENSP00000261187

    UniGene: Hs.439643