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SLC13A3 Antibody

  • 货号：
    CSB-PA442952
  • 规格：
    ￥1100
  • 图片：
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human plasma, Human placenta tissue, Primary antibody: CSB-PA442952(SLC13A3 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
  • 其他：

产品详情

  • Uniprot No.：
    Q8WWT9
  • 基因名：
    SLC13A3
  • 别名：
    dicarboxylate cotransporter 3 antibody; H sapiens mRNA for hepatocyte nuclear factor 4 gamma antibody; hNaDC3 antibody; Na antibody; Na(+)/dicarboxylate cotransporter 3 antibody; NaDC 3 antibody; NaDC-3 antibody; NADC3 antibody; S13A3_HUMAN antibody; SDCT 2 antibody; SDCT2 antibody; SLC13A3 antibody; Sodium dependent high affinity dicarboxylate transporter 2 antibody; Sodium dependent high affinity dicarboxylate transporter 3 antibody; Sodium-dependent high-affinity dicarboxylate transporter 2 antibody; Solute carrier family 13 (sodium dependent dicarboxylate transporter); member 3 antibody; Solute carrier family 13 member 3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human SLC13A3
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-6 carbon atoms, including succinate, alpha-ketoglutarate and N-acetylaspartate. The stoichiometry is probably 3 Na(+) for 1 divalent succinate.
  • 基因功能参考文献：
    1. NaDC3-related immunostaining was detected in the basolateral membrane of proximal tubules and in the basolateral membrane and/or luminal membrane of principal cells in connecting segments and collecting ducts PMID: 27053689
    2. OAT1 and NaDC3 in the basolateral membrane and OAT4 in the luminal membrane of proximal tubule cells are responsible for the avid renal secretion of N-carbamoylglutamate. PMID: 25354943
    3. In a study addressing genetic, social, and environmental contributors of chronic kidney disease with tubulointerstitial damages in Sri Lanka, SNP rs6066043 of SLC13A3 was found attributable risk of 50%. PMID: 24351856
    4. study concludes NaDC3 present at the basolateral membrane of proximal tubule cells mediates sodium-dependent glutathione (GSH) uptake; the kinetic data show that NaDC3 is a low-affinity GSH transporter PMID: 24247155
    5. The data 1) reveal alpha-ketoglutarate as a common high-affinity substrate of NaDC3, OAT1, and OAT3 PMID: 21865262
    6. The results indicate that SLC13A3 is a direct downstream target of PITX2 transcriptional regulation and that levels of PITX2 and SLC13A3 modulate responses to oxidative stress in ocular cells. PMID: 21873665
    7. NaDC3 promotes cellular senescence probably by inhibiting NAD(+)-dependent SIRT1. PMID: 20813124
    8. The narrow substrate specificity prevents interaction of drugs with dicarboxylate-like structure with hNaDC-3 and ensures sufficient support of the proximal tubule cells with alpha-ketoglutarate for anion secretion via organic anion transporter 1 or 3. PMID: 15561973
    9. We provide direct evidence of the localization of NaDC3 at the basolateral membrane of human renal proximal tubule cells and identify a di-hydrophobic amino acid motif VW as basolateral localization signal in the N-terminal cytoplasmic domain of NaDC3. PMID: 16331647

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    SLC13A/DASS transporter (TC 2.A.47) family, NADC subfamily
  • 组织特异性：
    Expression is highest in kidney. Detected in placenta, brain, liver and pancreas.
  • 数据库链接：

    HGNC: 14430

    OMIM: 606411

    KEGG: hsa:64849

    STRING: 9606.ENSP00000279027

    UniGene: Hs.655498