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SLA Antibody

  • 货号：
    CSB-PA613387LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: SLA antibody at 5µg/ml
      Lane 1: 293T whole cell lysate
      Lane 2: A431 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 32, 20, 34, 28, 36 kDa
      Observed band size: 32 kDa
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA613387LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA613387LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA613387LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SLA Polyclonal antibody
  • Uniprot No.：
    Q13239
  • 基因名：
    SLA
  • 别名：
    hSLAP antibody; SLA 1 antibody; sla antibody; SLA1 antibody; SLAP 1 antibody; SLAP antibody; SLAP-1 antibody; SLAP1 antibody; SLAP1_HUMAN antibody; Src like adapter antibody; Src like adapter protein 1 antibody; Src like adaptor antibody; SRC-like-adapter antibody; Src-like-adapter protein 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Src-like-adapter protein (2-276AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SLA Antibody (CSB-PA613387LA01HU)，的标记方式是Non-conjugated。对于SLA Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA613387LB01HU SLA Antibody, HRP conjugated ELISA
    FITC CSB-PA613387LC01HU SLA Antibody, FITC conjugated
    Biotin CSB-PA613387LD01HU SLA Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.
  • 基因功能参考文献：
    1. results suggest that cytoplasm-specific transduction of the SH3 and SH2 domains of SLAP has a therapeutic potential of being an immunosuppressive reagent for the treatment of various autoimmune diseases PMID: 25800872
    2. Taken together the data demonstrate that SLAP negatively regulates wild-type c-Kit signaling, but not its oncogenic counterpart, indicating a possible mechanism by which the oncogenic c-Kit bypasses the normal cellular negative feedback control PMID: 24284075
    3. upon ligand stimulation SLAP stably associates with Flt3 through multiple phosphotyrosine residues in Flt3. SLAP mRNA is differentially expressed in different cancers and its expression significantly increased in patients carrying the Flt3-ITD mutation PMID: 23300935
    4. These data provide evidence for src-like adaptor protein-dependent regulation of CD3 zeta-chain in the fine control of TCR signaling. PMID: 22798681
    5. Although SLA is a prominent glucocorticoids response gene, it does not seem to contribute to the anti-leukemic effects of glucocorticoids. PMID: 19631983
    6. The SLA molecule and its functionally relevant residues have been highly conserved throughout the evolution. PMID: 16521218

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  • 亚细胞定位：
    Cytoplasm. Endosome.
  • 组织特异性：
    Expressed in lung and fetal brain. Weakly expressed in heart, adult brain, placenta, liver, skeletal muscle, kidney and pancreas.
  • 数据库链接：

    HGNC: 10902

    OMIM: 601099

    KEGG: hsa:6503

    STRING: 9606.ENSP00000394049

    UniGene: Hs.75367