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SKAP2 Antibody

  • 货号：
    CSB-PA021355DSR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA021355DSR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SKAP2 Polyclonal antibody
  • Uniprot No.：
    O75563
  • 基因名：
    SKAP2
  • 别名：
    Fyn associated phosphoprotein SKAP55 homologue antibody; MGC10411 antibody; MGC33 antibody; PRAP antibody; Pyk2/RAFTK associated protein antibody; Pyk2/RAFTK-associated protein antibody; RA70 antibody; Retinoic acid-induced protein 70 antibody; SAPS antibody; SKAP-55HOM antibody; SKAP-HOM antibody; skap2 antibody; SKAP2_HUMAN antibody; SKAP55 homolog antibody; SKAP55R antibody; Src associated adaptor protein antibody; Src family associated phosphoprotein 2 antibody; Src family-associated phosphoprotein 2 antibody; src kinase associated phosphoprotein of 55 related protein antibody; Src kinase-associated phosphoprotein 2 antibody; Src kinase-associated phosphoprotein 55-related protein antibody; Src-associated adapter protein with PH and SH3 domains antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Src kinase-associated phosphoprotein 2 protein (1-120AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway.
  • 基因功能参考文献：
    1. Macrophages assemble the appropriate motile machinery to infiltrate tumors and promote disease progression, and implicate SKAP2 as an attractive candidate for therapeutically targeting TAMs. PMID: 26577701
    2. Skap2 is necessary for macrophage migration, chemotaxis, global actin reorganization and local actin reorganization upon integrin engagement. PMID: 22976304
    3. SKAP2 expression levels in NSCLC tissues could be a powerful biomarker of poor prognosis. Therefore, SKAP2 is a promising candidate molecular target for Non-small cell lung cancer treatment. PMID: 25862907
    4. results suggest that SKAP2 negatively regulates cell migration and tumor invasion in fibroblasts and glioblastoma cells by suppressing actin assembly induced by the WAVE2-cortactin complex PMID: 23161539
    5. analysis of substrate specificity of lymphoid-specific tyrosine phosphatase (Lyp) and identification of Src kinase-associated protein of 55 kDa homolog (SKAP-HOM) as a Lyp substrate PMID: 21719704
    6. cloning & characterization of an adaptor protein that functions as a downstream target for RAFTK & plays a role in alpha-synuclein phosphorylation PMID: 12893833
    7. studies provide insights into the molecular mechanism ofrelated adhesion focal tyrosine kinase (RAFTK) autophosphorylation and the specific role of Src in the regulation of RAFTK activation PMID: 15166227
    8. Overexpression of SKAP2 is associated with the development of pancreatic ductal adenocarcinoma PMID: 17952125

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    SKAP family
  • 组织特异性：
    Ubiquitously expressed. Present in platelets (at protein level).
  • 数据库链接：

    HGNC: 15687

    OMIM: 605215

    KEGG: hsa:8935

    STRING: 9606.ENSP00000005587

    UniGene: Hs.200770