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SIX6 Antibody

  • 货号：
    CSB-PA004096
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of COLO205 cells using Six3/6 Polyclonal Antibody
    • Western Blot analysis of RAT-MUSCLE cells using Six3/6 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    O95475
  • 基因名：
    SIX6
  • 别名：
    Homeobox protein SIX6 antibody; Homeodomain protein OPTX2 antibody; MCOPCT 2 antibody; MCOPCT2 antibody; Optic homeobox 2 antibody; OPTX 2 antibody; OPTX2 antibody; Sine oculis homeobox homolog 6 antibody; SIX 6 antibody; Six 9 antibody; SIX homeobox 6 antibody; Six6 antibody; SIX6_HUMAN antibody; Six9 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Six3/6.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May be involved in eye development.
  • 基因功能参考文献：
    1. The results suggest that SIX6 influences different stages of RGC differentiation and their survival; therefore, alteration in SIX6 function due to the risk allele may lead to cellular and molecular abnormalities. PMID: 28792678
    2. We replicated the association of SNP rs10483727 in the SIX1/SIX6 locus with POAG in a Saudi cohort, suggesting its role in increasing susceptibility to Primary Open Angle Glaucoma . PMID: 29190129
    3. Among 8 SNPs in 3 loci that showed at least nominal association (P < 5.00E-02) in the primary cohort, a representative SNP for each loci (rs2157719 for CDKN2B-AS1, rs33912345 for SIX6, and rs9913911 for GAS7) were selected PMID: 29261660
    4. elevated expressions of SIX2, SIX4, and SIX6 predicted poor overall survival (OS) in NSCLC and poor relapse-free survival (RFS) in lung adenocarcinoma PMID: 27821176
    5. study replicated the association of POAG with two SNPs at the SIX1-SIX6 locus and demonstrated that SNPs, rs10483727 and rs33912345, are significantly associated with POAG, especially with NTG in patients aged above 40 years PMID: 27260188
    6. Six1 regulates p53 via a dual mechanism involving upregulation of microRNA-27a and downregulation of RPL26. PMID: 26687066
    7. Single nucleotide polymorphism in SIX6 gene is associated with primary open angle glaucoma. PMID: 25798827
    8. SIX6 and/or intraocular pressure promotes primary open-angle glaucoma by directly increasing p16INK4a expression. PMID: 26365380
    9. we report a homozygous missense mutation of SIX6 associated with a unique eye phenotype characterized by optic disc anomalies, macular atrophy, and coloboma of the iris and chorioretina. PMID: 24702266
    10. Nonglaucomatous individuals with the SIX6 missense variant have reduced RNFL thickness in regions known to be particularly affected in those with glaucoma. PMID: 25537207
    11. Our results, in combination with previous SIX6 work, lead us to hypothesize that SIX6 risk variants disrupt the development of the neural retina, leading to a reduced number of retinal ganglion cells. PMID: 24875647
    12. Our findings in humans and zebrafish suggest a functional involvement of six6b in early eye development, and open new insights into the genetic architecture of POAG. PMID: 24150847
    13. No evidence was found that SIX6 mutations underlie human congenital structural eye malformations. PMID: 15505031
    14. Six6 and Six2 differ in their DNA-binding mechanisms and in the consequences of their interaction with protein tyrosine phosphatase Eyes Absent in Six2/6-DNA-binding ability. PMID: 18293925
    15. BOR and OAVS features are associated with duplication of SIX1, SIX6 and OTX2 resulting from a complex chromosomal rearrangement. PMID: 18666230

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  • 相关疾病：
    Optic disk anomalies with retinal and/or macular dystrophy (ODRMD)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    SIX/Sine oculis homeobox family
  • 组织特异性：
    Expressed in the developing and adult retina. Also expressed in the hypothalamic and the pituitary regions.
  • 数据库链接：

    HGNC: 10892

    OMIM: 212550

    KEGG: hsa:4990

    STRING: 9606.ENSP00000328596

    UniGene: Hs.194756