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SIRT4 Antibody

  • 货号：
    CSB-PA094289
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA094289(SIRT4 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA094289(SIRT4 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q9Y6E7
  • 基因名：
    SIRT4
  • 别名：
    MGC130046 antibody; MGC130047 antibody; MGC57437 antibody; NAD dependent deacetylase sirtuin 4 antibody; NAD dependent protein deacetylase sirtuin 4 antibody; NAD-dependent ADP-ribosyltransferase sirtuin-4 antibody; NAD-dependent protein deacetylase sirtuin-4 antibody; NAD-dependent protein lipoamidase sirtuin-4, mitochondrial antibody; Regulatory protein SIR2 homolog 4 antibody; Silent mating type information regulation 2 homolog antibody; Sir 2 like 4 antibody; SIR 2 like protein 4 antibody; Sir2 like 4 antibody; SIR2 like protein 4 antibody; SIR2-like protein 4 antibody; SIR2L 4 antibody; SIR2L4 antibody; SIR4_HUMAN antibody; SIRT 4 antibody; Sirt4 antibody; Sirtuin (silent mating type information regulation 2 homolog) 4 antibody; Sirtuin (silent mating type information regulation 2 homolog) 4 (S. cerevisiae) antibody; Sirtuin 4 antibody; Sirtuin type 4 antibody; Sirtuin-4 antibody; Sirtuin4 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human SIRT4
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest. In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor. Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis. Does not seem to deacetylate PC. Controls fatty acid oxidation by inhibiting PPARA transcriptional activation. Impairs SIRT1:PPARA interaction probably through the regulation of NAD(+) levels. Down-regulates insulin secretion.
  • 基因功能参考文献：
    1. structural model of a complex of human Sirt4 and GDH in order to elucidate the molecular mechanism underlying the ADP-ribosylation of GDH by Sirt4 PMID: 29571013
    2. we propose that the SIRT4-OPA1 axis is causally linked to mitochondrial dysfunction and altered mitochondrial dynamics that translates into aging-associated decreased mitophagy based on an unbalanced mitochondrial fusion/fission cycle. PMID: 29081403
    3. SIRT4 protein levels in endometrioid adenocarcinoma were markedly lower than its non-neoplastic tissue counterpart (P< 0.001). PMID: 28582846
    4. Protein levels of SIRT 4 were significantly higher in HUVECs from HELLP pregnancies compared to control after 60 and 120 minutes of hypoxia. PMID: 27651178
    5. we found that knock-out of mitochondrial sirtuin sir-2.3, homologous to mammalian SIRT4, is protective in both chemical ischemia and hyperactive channel induced necrosis. This work suggests a deleterious role of SIRT4 during ischemic processes in mammals that must be further investigated PMID: 28820880
    6. miR-15b is a negative regulator of stress-induced SIRT4 expression, thereby counteracting senescence associated mitochondrial dysfunction and regulating the SASP and possibly organ aging, such as photoaging of human skin. PMID: 26959556
    7. SIRT4 overexpression inhibits the proliferation of colorectal cancer cells in vitro and in vivo. PMID: 26986234
    8. Thus, these results suggest that SIRT4 has essential roles in stress resistance and may be an important therapeutic target for cancer treatment. PMID: 26775843
    9. SIRT4 behaves as a tumor suppressor at the human tissue protein level. PMID: 26054687
    10. Overexpression of SIRT4 attenuated inflammation mediators in umbilical vein endothelial cells. PMID: 25331589
    11. SIRT4 has a tumour-suppressive function and may serve as a novel therapeutic target in colorectal cancer. PMID: 26086877
    12. Serum Sirt4 was inversely related to anthropometric and metabolic parameters and positively related to peak GH and IGF-1. PMID: 25466907
    13. C-terminal-binding protein (CtBP) was found to have an essential role in promoting glutaminolysis by directly repressing the expression of SIRT4. PMID: 25633289
    14. This study demonstrated that SIRT4 upregulation in the liver of non-alcoholic fatty liver disease patients. PMID: 25361925
    15. Until now, a mammalian cellular lipoamidase has not been characterized; this study discovered that SIRT4 can function with this enzymatic capacity in the mitochondria, and that PDH is a biological substrate; compared to its catalytic efficiency for deacetylation, SIRT4 exhibits far superior enzymatic activity for lipoyl- and biotinyl-lysine modifications. PMID: 25525879
    16. The present study shows low circulating levels of SIRT4 in obese patients with nonalcoholic fatty liver disease. PMID: 25045415
    17. regulates ATP levels via ANT2 and a feedback loop involving AMPK PMID: 24296486
    18. these results highlight the tumor-suppressive role of SIRT4 in Myc-induced B cell lymphoma and suggest that SIRT4 may be a potential target against Myc-induced and/or glutamine-dependent cancers. PMID: 24368766
    19. Study shows that mTORC1 promotes glutamine anaplerosis by activating glutamate dehydrogenase (GDH). This regulation requires transcriptional repression of SIRT4, the mitochondrial-localized sirtuin that inhibits GDH. Mechanistically, mTORC1 represses SIRT4 by promoting the proteasome-mediated destabilization of cAMP-responsive element binding 2. PMID: 23663782
    20. there is a negative correlation between SIRTs 1 and 4 and fasting plasma glucose, a positive correlation between SIRT4 mRNA levels and triglyceride/lipoprotein a levels, and a negative correlation between SIRT4 mRNA levels and HDL PMID: 21556116
    21. mitochondrial SIRT4 has a role in the regulation of insulin secretion PMID: 17715127

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  • 亚细胞定位：
    Mitochondrion matrix.
  • 蛋白家族：
    Sirtuin family, Class II subfamily
  • 组织特异性：
    Detected in vascular smooth muscle and striated muscle. Detected in insulin-producing beta-cells in pancreas islets of Langerhans (at protein level). Widely expressed. Weakly expressed in leukocytes and fetal thymus.
  • 数据库链接：

    HGNC: 14932

    OMIM: 604482

    KEGG: hsa:23409

    STRING: 9606.ENSP00000202967

    UniGene: Hs.50861