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SIM1 Antibody

  • 中文名称：
    SIM1兔多克隆抗体
  • 货号：
    CSB-PA021325LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of Hela cells with CSB-PA021325LA01HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SIM1 Polyclonal antibody
  • Uniprot No.：
    P81133
  • 基因名：
    SIM1
  • 别名：
    Single-minded homolog 1 (Class E basic helix-loop-helix protein 14) (bHLHe14), SIM1, BHLHE14
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Single-minded homolog 1 protein (347-434aa)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SIM1 Antibody (CSB-PA021325LA01HU)，的标记方式是Non-conjugated。对于SIM1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA021325LB01HU SIM1 Antibody, HRP conjugated ELISA
    FITC CSB-PA021325LC01HU SIM1 Antibody, FITC conjugated
    Biotin CSB-PA021325LD01HU SIM1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:100-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult.
  • 基因功能参考文献：
    1. SIM1 is part of the leptin-melanocortin system. PMID: 30297428
    2. SIM1 was highly methylated in the majority of the cervical cancer tissues. Hypermethylation of SIM1 led to a pronounced reduction in SIM1 expression in cervical cancer tissues compared with normal cervix. The degree of SIM1 methylation was significantly associated with the severity of the disease. PMID: 29063719
    3. Single nucleotide polymorphism rs3734354 in SIM1 gene is associated with severe early-onset obesity. PMID: 28593922
    4. identified a novel SIM1 variant, p.D134N, in 4 obese individuals from a single pedigree which is also associated with lower preference for certain foods PMID: 28472148
    5. no gene harboring deletions were identified in the SIM1 and MRAP2 regions in the Prader Willi like (PWL) cohort; further functional analysis of p.P352S found in SIM1 and p.A40S found in MRAP2 is useful; this would provide further support for possible role of SIM1 and MRAP2 in the pathogenesis of the PWL phenotype in a limited number of patients PMID: 26795956
    6. Genotype-phenotype correlations confirmed the major role for SIM1 haploinsufficiency in obesity and the Prader-Willi-like phenotype PMID: 25351778
    7. Aberrant DNA methylation of the DLX4 and SIM1 genes may be a novel progression marker for uterine cervical low-grade squamous intraepithelial lesions. PMID: 25614457
    8. Severe loss-of-function SIM1 mutations can be associated with a spectrum of developmental delay phenotypes and obesity. PMID: 25234154
    9. functional in vitro analysis of SIM1 variants may help in distinguishing benign variants of no pathogenic significance from variants which contribute to the obesity phenotype. PMID: 24097297
    10. Study found a statistically significant association between the SIM1 SNP rs3734354 (Pro352Thr) and scores for language impairment (p = .0004), but due to low statistical power this should be interpreted cautiously PMID: 24635660
    11. two brain enhancers in the SIM1 locus are characterized with a set of obesity-specific SNPs within one of them, which may predispose individuals to obesity. PMID: 24203700
    12. Data suggest selected SIM1 variants exhibit poor dimerization with ARNT2 (aryl-hydrocarbon receptor nuclear translocator 2) and anomalous intracellular localization; data were used to predict spot in SIM1/SIM2 (residues 290-326) critical in function. PMID: 24814368
    13. Hence, we suggest that detailed endocrine evaluation and longitudinal endocrine follow up be performed in individuals with proximal interstitial 6q deletion involving SIM1 PMID: 24038875
    14. A link between SIM1 loss of function and severe obesity associated with, or independent of, Prader-Willi-like features. PMID: 23778136
    15. Phenotypic similarities between patients with SIM1 deficiency and MC4R deficiency suggest that some of the effects of SIM1 deficiency on energy homeostasis are mediated by altered melanocortin signaling. PMID: 23778139
    16. Data indicate that median methylation levels of BCAN, HOXD1, KCTD8, KLF11, NXPH1, POU4F1, SIM1, and TCF7L1 were >/=30% higher than in normal samples, representing potential biomarkers for tumor diagnosis. PMID: 22930747
    17. TagSNP analysis of SIM1 revealed two SNPs in the 3' region (rs9390322 and rs7746743) and another in intron 5 (rs3734353) to be significantly associated with various adiposity measures in ethnicity- and sex-specific manners... PMID: 21512513
    18. Our study excludes a major contribution of SIM1 common variants in exons, 5' and 3' UTR regions in polygenic obesity susceptibility in French Europeans. PMID: 20075856
    19. Hyperphagic obesity in single-minded homolog 1 (Sim1)-deficient mice may be attributable to transgenic changes in the leptin-melanocortin-oxytocin pathway. PMID: 20220015
    20. Haploinsufficiency of the SIM1 gene might be responsible for the severe obesity observed in a child with a Prader-Willi-like phenotype. PMID: 12161602
    21. SIM1 and SIM2 have a novel nuclear localization signal PMID: 14697214
    22. SIM1 transgene completely rescued the hyperphagia and partially rescued the obesity of agouti yellow mice PMID: 16709610
    23. Common variation in SIM1 is associated with body mass index on a population level in Pima Indians where the risk allele is the major allele. PMID: 19401419

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 10882

    OMIM: 603128

    KEGG: hsa:6492

    STRING: 9606.ENSP00000262901

    UniGene: Hs.520293