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SHPK Antibody

  • 货号：
    CSB-PA833951
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from Jurkat cells, using CARKL antibody.
    • Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue using CARKL antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SHPK Polyclonal antibody
  • Uniprot No.：
    Q9UHJ6
  • 基因名：
    SHPK
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from N-terminal of Human CARKL.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a modulator of macrophage activation through control of glucose metabolism.
  • 基因功能参考文献：
    1. CARKL-dependent metabolic reprogramming is required for proper M1- and M2-like macrophage polarization PMID: 22682222
    2. the CARKL-encoded protein, sedoheptulokinase (SHK), is responsible for the reaction: sedoheptulose + ATP --> sedoheptulose-7-phosphate + ADP, and deletion of CARKL causes urinary accumulation of sedoheptulose and erythritol PMID: 18186520
  • 相关疾病：
    Sedoheptulokinase deficiency (SHPKD)
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    FGGY kinase family
  • 组织特异性：
    Strongly expressed in liver, kidney and pancreas. Expressed at lower levels in placenta and heart. Very weakly expressed in lung and brain.
  • 数据库链接：

    HGNC: 1492

    OMIM: 605060

    KEGG: hsa:23729

    STRING: 9606.ENSP00000225519

    UniGene: Hs.579217