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SHCBP1 Antibody

  • 货号：
    CSB-PA847699LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SHCBP1 Polyclonal antibody
  • Uniprot No.：
    Q8NEM2
  • 基因名：
    SHCBP1
  • 别名：
    FLJ22009 antibody; PAL antibody; Protein expressed in Activated Lymphocytes antibody; SHC binding and spindle associated 1 antibody; SHC SH2 domain-binding protein 1 antibody; SHCBP_HUMAN antibody; Shcbp1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human SHC SH2 domain-binding protein 1 protein (211-500AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SHCBP1 Antibody (CSB-PA847699LA01HU)，的标记方式是Non-conjugated。对于SHCBP1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA847699LB01HU SHCBP1 Antibody, HRP conjugated ELISA
    FITC CSB-PA847699LC01HU SHCBP1 Antibody, FITC conjugated
    Biotin CSB-PA847699LD01HU SHCBP1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells.
  • 基因功能参考文献：
    1. SHCBP1 was found highly expressed in SS cell lines and tissues, which was linked to the poor clinical prognosis and was implicated in SS aggressive progression. SHCBP1 regulated invasion and metastasis by modulating the TGF-beta1/Smad signaling pathway and promoting the EMT in SS. PMID: 29020987
    2. Data indicate that the oncogene SS18-SSX1 promotes tumorigenesis by increasing the expression of SHC SH2-domain binding protein 1 (SHCBP1), which normally acts as a tumor promoting factor. PMID: 27572315
    3. Immunohistochemical analysis revealed SHCBP1 was significantly up-regulated in breast cancer tissues compared with adjacent normal tissues (82 of 128, 64%). Over-expressed SHCBP1 was correlated with advanced clinical stage and poorer survival. Ablation of SHCBP1 inhibited the proliferation in vitro. PMID: 27129942
    4. This study gives novel insight into the role of SHCBP in cytokinesis completion. PMID: 25486361
    5. Knockdown of SHCBP1 induced cell cycle delay. PMID: 24289556
    6. The central region of SHCBP1 was found to bind to measles virus C protein, as well as the phosphoprotein, but the two viral proteins did not compete for SHCBP1 binding. PMID: 23804634

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  • 亚细胞定位：
    Midbody. Cytoplasm, cytoskeleton, spindle.
  • 数据库链接：

    HGNC: 29547

    OMIM: 611027

    KEGG: hsa:79801

    STRING: 9606.ENSP00000306473

    UniGene: Hs.123253