SH3GLB1 Antibody
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货号:CSB-PA106166
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规格:¥1100
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图片:
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其他:
产品详情
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Uniprot No.:Q9Y371
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基因名:
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别名:Bax interacting factor 1 antibody; Bax-interacting factor 1 antibody; Bif 1 antibody; Bif antibody; Bif-1 antibody; CGI 61 antibody; dJ612B15.2 antibody; Endophilin B1 antibody; Endophilin-B1 antibody; PPP1R70 antibody; Protein phosphatase 1 regulatory subunit 70 antibody; SH3 containing protein SH3GLB1 antibody; SH3 domain GRB2 like endophilin B1 antibody; SH3 domain-containing GRB2-like protein B1 antibody; Sh3glb1 antibody; SH3p13 antibody; SHLB1_HUMAN antibody
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宿主:Rabbit
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反应种属:Human,Mouse,Rat
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免疫原:Fusion protein of Human SH3GLB1
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免疫原种属:Homo sapiens (Human)
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标记方式:Non-conjugated
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抗体亚型:IgG
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纯化方式:Antigen affinity purification
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浓度:It differs from different batches. Please contact us to confirm it.
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保存缓冲液:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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产品提供形式:Liquid
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应用范围:ELISA,IHC
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推荐稀释比:
Application Recommended Dilution ELISA 1:2000-1:5000 IHC 1:25-1:100 -
Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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靶点详情
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功能:May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion. Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation. Isoform 1 acts proapoptotic in fibroblasts. Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC...显示更多
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基因功能参考文献:
- Here the s report that Endophilin B2, similarly to Endophilin B1, plays an indispensable role in mitochondria sequestration and inner mitochondrial membrane (IMM) protein degradation during mitophagy. PMID: 27112121
- endophilin B1 participates in dynamin 2-dependent formation of a population of transport vesicles distinct from those generated by A-type endophilins PMID: 27508440
- Bif-1 is involved in prostate cancer tumorigenesis and acts as a suppressor in prostate cancer progression. PMID: 27748942
- endophilin B1 mediated the biological function of EGFR in cancer cell proliferation through regulating the EGFR endocytic trafficking and downstream signaling. PMID: 27609472
- these data reveal an Irgm1-dependent mechanism that promotes the tumorigenesis of melanoma via dual regulation of apoptosis and Bif-1-dependent autophagy PMID: 25619828
- Our findings suggest that endophilin-B1 is a key mediator of a feed-forward mechanism of Alzheimer's disease pathogenesis PMID: 25981964
- Data suggest that activated autophagy is associated with the progression of pancreatic ductal adenocarcinoma and that the overexpression of autophagy-related proteins Atg5, Ambra1, beclin-1, LC3B and Bif-1 is significantly correlated with poor outcome. PMID: 23429496
- these data suggest a novel function for Bif-1 as a suppressor of breast cancer cell migration by promoting EGFR degradation through the regulation of endosome maturation PMID: 22785202
- The expression of Bif-1 is downregulated in a subset of pancreatic ductal adenocarcinoma. This novel finding is in agreement with the tumor suppressor function of Bif-1. PMID: 21283040
- These findings suggest that Bif-1 acts as a critical regulator of Atg9 puncta formation presumably by mediating Golgi fission for autophagosome biogenesis during starvation. PMID: 21068542
- GSK-3beta promotes cell survival by modulating Bif-1-dependent autophagic response and cell death. PMID: 20159967
- Double knockdown of endophilin B1 and Drp1 leads to a mitochondrial phenotype identical to that of the Drp1 single knockdown, a result consistent with Drp1 acting upstream of endophilin B1 in the maintenance of morphological dynamics of mitochondria. PMID: 15452144
- Bif-1 is an important component of the mitochondrial pathway for apoptosis as a novel Bax/Bak activator, and loss of this proapoptotic molecule may contribute to tumorigenesis. PMID: 16227588
- BAR domain of endophilin-A1 drives membrane curvature by coordinate action of the crescent's scaffold mechanism and the ridge's membrane insertion in addition to membrane binding via amino-terminal amphipathic helix. PMID: 16763557
- The decreased expression of Bif-1 in malignant gastric epithelial cells compared with the normal mucosal cells suggests that loss of Bif-1 expression may play a role in gastric tumorigenesis, possibly by inhibiting the apoptosis mediated by Bif-1. PMID: 16916719
- Src phosphorylation of Bif-1 suppresses the interaction between Bif-1 and Bax, resulting in the inhibition of Bax activation during anoikis. PMID: 18474606
- Bif-1 expression might play a role in tumorigenesis in both urinary bladder (UB) and gallbladder (GB) cancer PMID: 18752120
- The loss of Bif-1 expression in a subset of prostate cancer samples is in agreement with the proapoptotic function of Bif-1. PMID: 18824435
- down-regulation of Bif-1 during the transition from normal colorectal mucosa to colorectal adenocarcinoma PMID: 18833585
- upregulation of Bif-1 could in part be responsible for tumorigenesis in cutaneous Merkel cell carcinoma PMID: 19125733
- Deregulation of Bif-1-related cell death is dependent not on Bif-1 mutation but on other mechanisms. PMID: 19132989
- Bax activates endophilin B1 oligomerization and lipid membrane vesiculation PMID: 19805544
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亚细胞定位:Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Mitochondrion outer membrane; Peripheral membrane protein. Cytoplasmic vesicle, autophagosome membrane. Midbody.
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蛋白家族:Endophilin family
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组织特异性:Highly expressed in heart, skeletal muscle, kidney and placenta. Detected at lower levels in brain, colon, thymus, spleen, liver, small intestine, lung and peripheral blood leukocytes.
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数据库链接:
HGNC: 10833
OMIM: 609287
KEGG: hsa:51100
UniGene: Hs.136309