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SH3GL2 Antibody

  • 货号：
    CSB-PA050049
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q99962
  • 基因名：
  • 别名：
    bA335L15.1 (SH3 domain GRB2 like 2) antibody; CNSA2 antibody; EEN B1 antibody; EEN-B1 antibody; Endophilin 1 antibody; Endophilin A1 antibody; Endophilin A1 BAR domain antibody; Endophilin-1 antibody; Endophilin-A1 antibody; FLJ20276 antibody; FLJ25015 antibody; OTTHUMP00000021084 antibody; SH3 domain containing GRB2 like protein 2 antibody; SH3 domain GRB2 like 2 antibody; SH3 domain protein 2A antibody; SH3 domain-containing GRB2-like protein 2 antibody; SH3D2A antibody; SH3G2_HUMAN antibody; Sh3gl2 antibody; Sh3p4 antibody; SH3PA antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Endophilin I.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes.
  • 基因功能参考文献：
    1. The results suggest that SH3GL2 suppresses migration and invasion behaviors of glioma cells through negatively regulating STAT3/MMP2 signaling. PMID: 28470949
    2. Alix acts in concert with endophilin A to promote clathrin-independent endocytosis of cholera toxin and to regulate cell migration. PMID: 27244115
    3. This study identified a new mitochondria reprogramming pathway influencing breast cancer progression through SH3GL2 and MFN2. These proteins were frequently lost in breast cancer, which was traceable in the circulating exosomes. PMID: 26888829
    4. Endophilin-1 was a direct and functional downstream target of miR-107. PMID: 27038654
    5. Methylation status of SH3GL2 gene was associated with the TNM staging and HPV infection status of vulvar squamous cell carcinoma. PMID: 26823912
    6. Endophilin-1 positively regulated blood-brain barrier permeability via the EGFR-JNK signaling pathway in hCMEC/D3 cells, which would provide an experimental basis for further research on endophilin-1 mediated the opening of blood-brain barrier . PMID: 25721793
    7. these results reveal a novel function of postsynaptic endophilin A1 in spine morphogenesis, stabilization and synaptic function through the regulation of p140Cap PMID: 25771685
    8. Data indicate that the presence of the susceptible G allele in SNP rs1049430 is associated with the inactivation of SH3-domain GRB2-like 2 protein (SH3GL2) and could be used as a prognostic marker of head and neck squamous cell carcinoma (HNSCC). PMID: 25728707
    9. study described that endophilin-1 is expressed in hCMEC/D3 cells where it regulates the permeability of blood-brain barrier by altering the expression of ZO-1 and occludin via the EGFR-ERK1/2 pathway PMID: 24854121
    10. miR-330 negatively regulated the expression of SH3GL2 in GSCs, which promoted the oncogenic progression of GSCs through activating ERK and PI3K/AKT signaling pathways. PMID: 24736727
    11. these findings identify loss of Sh3gl2 as a frequent event in Urothelial carcinoma (UC) development that promotes disease progression. PMID: 23814487
    12. this study suggests a novel mechanism in which Lpd mediates EGFR endocytosis via Mena downstream of endophilin. PMID: 24076656
    13. Overexpression of EGFR in head and neck squamous cell carcinoma is associated with inactivation of SH3GL2 and CDC25A genes. PMID: 23675485
    14. Data suggest that expression of endothelin-1 and vWF (von Willebrand factor) is up-regulated and eNOS (endothelial nitric oxide synthase) activity is increased in radial artery in diabetic patients with coronary artery disease. PMID: 22972845
    15. Our results indicate that SH3GL2 is frequently deleted in NSCLC and regulates cellular growth and invasion by modulating EGFR function. PMID: 22968441
    16. SH3GL2 gene was identified as the target of miR-330. miRNA-330 plays an oncogenic role in human glioblastoma by regulating SH3GL2 gene and might be a new therapeutic target of human glioblastoma. PMID: 23029364
    17. simulations constitute a multi-dimensional exploration of how EGF-dependent EGFR endocytosis and ERK activation are dynamically affected by scaffolds KSR and MP1, co-regulated by Cbl-CIN85 and Endophilin A1 PMID: 21829671
    18. Alterations of SH3GL2 and CDKN2A loci have a synergistic role in the development of early-onset breast cancer. PMID: 18239974

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  • 亚细胞定位：
    Cytoplasm. Membrane; Peripheral membrane protein. Early endosome. Cell junction, synapse, presynapse.
  • 蛋白家族：
    Endophilin family
  • 组织特异性：
    Brain, mostly in frontal cortex. Expressed at high level in fetal cerebellum.
  • 数据库链接：

    HGNC: 10831

    OMIM: 604465

    KEGG: hsa:6456

    STRING: 9606.ENSP00000369981

    UniGene: Hs.743740