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SH3BP4 Antibody

  • 货号：
    CSB-PA021225GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9P0V3
  • 基因名：
    SH3BP4
  • 别名：
    BOG25 antibody; EH binding protein antibody; EH binding protein 10 antibody; EH-binding protein 10 antibody; EHB10 antibody; SH3 domain binding protein 4 antibody; SH3 domain-binding protein 4 antibody; SH3B4_HUMAN antibody; sh3bp4 antibody; Transferrin receptor trafficking protein antibody; Transferrin receptor-trafficking protein antibody; TTP antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human SH3BP4
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy.
  • 基因功能参考文献：
    1. SH3BP4 has been identified as a novel pigmentation gene. The SH3BP4 is a direct target of miR-125b. The SH3BP4 is transcriptionally regulated by MITF as its direct target. PMID: 28819321
    2. SH3BP4 is a negative regulator of the Rag GTPase complex and amino acid-dependent mTORC1 signaling. PMID: 22575674
    3. Results show that TTP (SH3BP4), a SH3-containing protein, specifically regulates the internalization of the transferrin receptor (TfR). PMID: 16325581
  • 亚细胞定位：
    Membrane, clathrin-coated pit. Cytoplasmic vesicle, clathrin-coated vesicle. Nucleus. Note=Specifically associated with transferrin receptor-containing clathrin-coated pits and clathrin-coated vesicles. May also localize to the nucleus.
  • 组织特异性：
    Expressed in all tissues tested with higher expression in pancreas. Expressed by retinal pigment epithelial cells (at protein level).
  • 数据库链接：

    HGNC: 10826

    OMIM: 605611

    KEGG: hsa:23677

    STRING: 9606.ENSP00000340237

    UniGene: Hs.516777