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SGCD Antibody

  • 中文名称：
    SGCD兔多克隆抗体
  • 货号：
    CSB-PA835688ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: RRAS2 antibody at 4.55µg/ml
      Lane 1: Mouse kidney tissue
      Lane 2: Mouse liver tissue
      Lane 3: Jurkat whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 33, 29 kDa
      Observed band size: 33 kDa
    • Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA835688ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA835688ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SGCD Polyclonal antibody
  • Uniprot No.：
    Q92629
  • 基因名：
    SGCD
  • 别名：
    35 kDa dystrophin associated glycoprotein antibody; 35 kDa dystrophin-associated glycoprotein antibody; 35DAG antibody; CMD1L antibody; DAGD antibody; Delta-sarcoglycan antibody; Delta-SG antibody; Dystrophin associated glycoprotein delta sarcoglycan antibody; LGMD2F antibody; MGC22567 antibody; Placental delta sarcoglycan antibody; Sarcoglycan delta (35 kDa dystrophin associated glycoprotein) antibody; SG delta antibody; SGCD antibody; SGCD_HUMAN antibody; SGCDP antibody; SGD antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Delta-sarcoglycan protein (60-289AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
  • 基因功能参考文献：
    1. Study identified 2 non-synonymous missense mutations: c.C652T, p.R218W in ACVRL1, c.C717G, p.D239E in SGCD in Chinese population with total anomalous pulmonary venous return. PMID: 28412737
    2. Dilated cardiomyopathy mutations in delta-sarcoglycan can exert a dominant negative effect on dystrophin-glycoprotein complex function leading to myocardial mechanical instability that may underlie the pathogenesis of delta-sarcoglycan-associated DCM. PMID: 26968544
    3. haplotype -_G composed of c.-100~-110 and A848G confers higher susceptibility to dilated cardiomyopathy in the Mongoloid population. PMID: 26720722
    4. CC genotype of the delta-sarcoglycan gene polymorphism rs13170573 is associated with obstructive sleep apnea in the Chinese population PMID: 25474115
    5. Genetic variation at the delta-sarcoglycan locus elevates heritable sympathetic nerve activity in human twin pairs PMID: 23786442
    6. Finding questions the pathological relevance of sequence variant of the delta-sarcoglycan gene for causing familial autosomal-dominant dilated cardiomyopathy. PMID: 19259135
    7. The 5'-UTR G to C polymorphism on delta-sarcoglycan gene was associated with coronary spasm in Japanese patients with hypertrophic cardiomyopathy. PMID: 17652892
    8. The limb-girdle muscular dystrophy patients with delta-sarcoglycan deficient LGMD2F do not enable an accurate prediction of the genotype. PMID: 18996010

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  • 相关疾病：
    Limb-girdle muscular dystrophy 2F (LGMD2F); Cardiomyopathy, dilated 1L (CMD1L)
  • 亚细胞定位：
    Cell membrane, sarcolemma; Single-pass type II membrane protein. Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Sarcoglycan beta/delta/gamma/zeta family
  • 组织特异性：
    Most strongly expressed in skeletal and cardiac muscle. Also detected in smooth muscle. Weak expression in brain and lung.
  • 数据库链接：

    HGNC: 10807

    OMIM: 601287

    KEGG: hsa:6444

    STRING: 9606.ENSP00000338343

    UniGene: Hs.387207