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  4. SET Antibody

SET Antibody

  • 货号：
    CSB-PA021099GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q01105
  • 基因名：
    SET
  • 别名：
    2PP2A antibody; HLA DR associated protein II antibody; HLA-DR-associated protein II antibody; I 2PP2A antibody; I-2PP2A antibody; I2PP2A antibody; IGAAD antibody; Inhibitor of granzyme A activated DNase antibody; Inhibitor of granzyme A-activated DNase antibody; Inhibitor of GzmA-activated DNase antibody; inhibitor-2 of protein phosphatase-2A antibody; IPP2A2 antibody; PHAPII antibody; Phosphatase 2A inhibitor I2PP2A antibody; protein phosphatase type 2A inhibitor antibody; Protein SET antibody; Set antibody; SET nuclear oncogene antibody; SET translocation antibody; SET translocation (myeloid leukemia-associated) antibody; SET_HUMAN antibody; TAF I antibody; TAF IBETA antibody; TAF-I antibody; TAFI antibody; Template activating factor I antibody; Template-activating factor I antibody; Template-Activating Factor-I, chromatin remodelling factor antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human SET
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher.
  • 基因功能参考文献：
    1. hsa_circ_0000673 promoted hepatocellular carcinoma malignant behaviors via regulating miR-767-3p/SET pathway. PMID: 29627570
    2. Findings indicate that TCE may induce hepatocyte apoptosis via SET-mediated dephosphorylation and overexpression of nucleolin. PMID: 28402964
    3. Recent studies showed that SET is overexpressed in breast cancers, ovary cancers and other malignancies. The strong correlation between SET expression levels and survival of ovarian cancer patients, and SET-mediated activation of androgen synthesis, strongly indicate a significant role in gynecologic cancers. Also, SET appears to exert its activity through PP2A-dependent as well as PP2A-independent mechanisms. [review] PMID: 28356029
    4. SET overexpression is associated with GC progression. PMID: 28677734
    5. The results demonstrate that NFkB plays an important role in regulation of the human SET gene expression. PMID: 27351675
    6. SET accumulation is implicated in epigenetic modifications, such as DNA hypomethylation and histone hypoacetylation. It is associated with gene expression regulation and chromatin organization, thereby affecting gene expression control, DNA damage repair, and genome instability. PMID: 28460463
    7. Data show that PP32 and SET/TAF-Ibeta proteins block HAT1-mediated H4 acetylation. PMID: 28977641
    8. SEToverexpression promotes morphological and oncogenic cell transformation of an oral keratinocyte cell. PMID: 28636114
    9. Overexpression of SET-Nup214 in HeLa cells leads to the formation of similar nuclear bodies that recruit CRM1, export cargo proteins, and certain nucleoporins and concomitantly affect nuclear protein and poly(A)(+) RNA export. PMID: 27613868
    10. Molecular chaperone SET-assisted eviction of linker histones and Shugoshins is a fundamental step in mammalian mitotic progression. PMID: 28781233
    11. Our findings suggested the oncogenic role of SET and the adverse prognostic value of SET overexpression in hepatocellular carcinoma (HCC). This alteration defines a subgroup of HCC patients who could benefit from SET antagonists, such as EMQA. PMID: 26876205
    12. This review summarizes and discusses the general mechanisms of H3K4 methylation, and how the six main enzymes from the SET/MLL family (responsible for H3K4me1/me2/me3) function in hematopoiesis and in hematologic malignancies. [review] PMID: 27796741
    13. identification of the oncoprotein SET as a major cellular factor whose binding with p53 is dependent on C-terminal domain acetylation status PMID: 27626385
    14. The findings of the present study suggested that the SET gene may contribute to tumorigenesis and may be a potential novel effective therapeutic target for leukemia and other cancer types. PMID: 27035430
    15. Data indicate that SET protein as a direct target of microRNA miR-125b, and the downregulation of SET, observed during tumor migration, was affected by the overexpression of miR125b. PMID: 27383536
    16. significance of SET/I2PP2A-mediated PP2A and non-PP2A pathways in polycystic ovary syndrome PMID: 27836688
    17. Both SET protein levels (and BACE1) were increased in Down syndrome patients. PMID: 24935721
    18. SET interacts with the Kruppel-associated box (KRAB)-associated co-repressor KAP1, and its overexpression results in the sustained retention of KAP1 and Heterochromatin protein 1 (HP1) on chromatin PMID: 25818296
    19. the results of the present study demonstrated that SET was associated with paclitaxel resistance in MCF-7/PTX cells, and that paeonol reversed paclitaxel resistance in MCF-7/PTX cells by downregulating the activity of the SET/PP2A/Akt pathway. PMID: 25760096
    20. These findings establish a framework for understanding the molecular basis of cytochrome c-mediated blocking of SET/TAF-Ibeta. PMID: 26216969
    21. Low SET expression is associated with bone metastasis in renal cell carcinoma. PMID: 26115722
    22. SET overexpression is a frequent event in metastatic colorectal cancer that plays a potential oncogenic role associated with worse outcome and resistance to oxaliplatin. PMID: 25388166
    23. A functional link between SET-mediated NDRG1 regulation. PMID: 25152373
    24. Therefore, SET overexpression in HEK293 cells promotes mitochondrial fission and reduces autophagic flux in apparent association with up-regulation of UCP2 and UCP3. PMID: 25656576
    25. The stable suppression of SET through RNA interference inhibited the growth, migration and invasion of breast cancer cells. Knockdown of SET increased the activity and expression of PP2Ac and decreased the expression of matrix metalloproteinase 9. PMID: 25234598
    26. Data indicate a therapeutic paradigm of inhibitor-2 of protein phosphatase-2A (SET) antagonism using OP449 in combination with tyrosine kinase inhibitors for the treatment of chronic myeloid leukemia (CML) and acute myeloid leukemia (AML) cell lines. PMID: 24436473
    27. Inactivation of nuclear localization signal causes retention of I2PP2A in the cell cytoplasm, where it promotes Tau hyperphosphorylation by affecting PP2A signaling. PMID: 25128526
    28. SET/TAF-Ibeta inhibits FoxO1 acetylation and activates its transcriptional activity toward p21 PMID: 24983498
    29. SET accumulation has important actions in head and neck squamous cell carcinoma PMID: 24555657
    30. SET/TAF-Ibeta interacts with Ku70/80 in the nucleus and inhibits Ku70 acetylation. PMID: 24305947
    31. SET is overexpressed in about 50-60% and CIP2A in about 90% of breast cancers. PMID: 24927563
    32. Set-beta differentially regulates axon growth and regeneration depending on subcellular localization and phosphorylation. PMID: 24849368
    33. C6-ceramide inhibits I2PP2A mediated upregulation of c-Myc and downregulation of histone acetylation in prostate cancer cells. PMID: 24025258
    34. When compared with SET-NUP214-negative patients, SET-NUP214-positive patients showed a significantly higher rate of corticosteroid resistance (91% vs 44%; P = .003) and chemotherapy resistance (100% vs 44%; P = .0001). PMID: 24449214
    35. Data show that SET accumulation up-regulated hnRNPK mRNA and total/phosphorylated protein, promoted hnRNPK nuclear location, and reduced Bcl-x mRNA levels. PMID: 24508256
    36. Detention of cytoplasmic SET protein occurs with Ser9 phosphorylation in Alzheimer's disease. PMID: 23374587
    37. TAF-Ibeta promotes BZLF1 expression and subsequent lytic infection by affecting chromatin at the BZLF1 promoter PMID: 23691099
    38. Recombinant SET with phosphorylation-mimic Ser171 to Glu substitution reduced its inhibitory effects on PP2A phosphatase activity compared with Ser171 to Ala substituted or wild-type SET PMID: 23251465
    39. SET is potential marker for head and neck squamous cell carcinoma associated with cancer cell resistance PMID: 22739068
    40. SET protein interacts with intracellular domains of the gonadotropin-releasing hormone receptor and differentially regulates receptor signaling to cAMP and calcium in gonadotrope cells PMID: 23233674
    41. A SET mutant, lacking a nuclear localization signal, SET(DeltaNLS), promotes cell spreading and motility. This was accompanied by an increase in the number and frequency of membrane ruffles. PMID: 23195690
    42. SET downregulated repair genes ATM, BRCA1 and CHEK2 and upregulated TP53 PMID: 23106910
    43. SET/TAF-Ibeta is sequentially recruited to the target gene promoter ATF3 after the PRC2 complex via H3K27me recognition and may offer additive effects in the repression of the target gene. PMID: 22796192
    44. SET knockdown increased high-affinity binding of agonist in intact cells and membrane preparations. PMID: 22466417
    45. Results showed that SET is significantly overexpressed in pediatric acute lymphoblastic leukemia samples, and an increased level of SET might contribute to leukemic process. PMID: 22677993
    46. SET overexpression is a key mechanism in the inhibition of PP2A in acute myeloid leukemia. PMID: 22133779
    47. Suggest that accumulated SET could act via Akt/PTEN either as cell survival signal or as oxidative stress sensor for cell death. PMID: 22143534
    48. Data describe the relatively high incidence of SET-NUP214 rearrangement in adult T-ALLs, and demonstrate comprehensive clinical, phenotypic, and genetic characteristics of this entity. PMID: 21720744
    49. crystals of template-activating factor Ibeta diffracted to 2.7 A resolution and belonged to space group P4(3)2(1)2. PMID: 20693670
    50. TAF-I is a key molecule that regulates linker histone-mediated chromatin assembly and disassembly PMID: 21940793

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  • 相关疾病：
    A chromosomal aberration involving SET is found in some cases of acute undifferentiated leukemia (AUL). Translocation t(6;9)(q21;q34.1) with NUP214/CAN.
  • 亚细胞定位：
    Cytoplasm, cytosol. Endoplasmic reticulum. Nucleus, nucleoplasm. Note=In the cytoplasm, found both in the cytosol and associated with the endoplasmic reticulum. The SET complex is associated with the endoplasmic reticulum. Following CTL attack and cleavage by GZMA, moves rapidly to the nucleus, where it is found in the nucleoplasm, avoiding the nucleolus. Similar translocation to the nucleus is also observed for lymphocyte-activated killer cells after the addition of calcium.
  • 蛋白家族：
    Nucleosome assembly protein (NAP) family
  • 组织特异性：
    Widely expressed. Low levels in quiescent cells during serum starvation, contact inhibition or differentiation. Highly expressed in Wilms' tumor.
  • 数据库链接：

    HGNC: 10760

    OMIM: 600960

    KEGG: hsa:6418

    STRING: 9606.ENSP00000361777

    UniGene: Hs.436687