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SERPIND1 Antibody

  • 货号：
    CSB-PA009123
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    P05546
  • 基因名：
  • 别名：
    D22S673 antibody; HC II antibody; HC-II antibody; HC2 antibody; HCF2 antibody; HEP2_HUMAN antibody; Heparin cofactor 2 antibody; Heparin cofactor II antibody; HLS2 antibody; Leuserpin 2 antibody; LS2 antibody; Protease inhibitor leuserpin 2 antibody; Protease inhibitor leuserpin-2 antibody; serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1 antibody; Serpin D1 antibody; serpin peptidase inhibitor, clade D (heparin cofactor), member 1 antibody; SERPIND1 antibody; THPH10 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human HC-II.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner.; Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils.
  • 基因功能参考文献：
    1. Loss of Heparin Cofactor is associated with insulin resistance . PMID: 28502917
    2. The plasma level of alpha2M was found positively correlated, while HCII level was negatively correlated with higher vulnerability of carotid plaques. Both proteins were efficient in differentiating stable and vulnerable carotid plaques. These provide potential new targets for the research of carotid plaque vulnerability. Plasma alpha2M and HCII may be potential biomarkers for evaluation of the vulnerability of carotid ... PMID: 28087279
    3. We found that SERPIND1 may act as a potential oncogene in the development of ovarian cancer PMID: 27430660
    4. Molecular modelling of HCII 1-75 predicted those portions of the acidic extension that had been previously visualized in crystal structures, and suggested that an alpha-helix found between residues 26 and 36 stabilizes one found between residues 61-67. PMID: 23496873
    5. heparin co-factor II is a novel metastasis enhancer and may be used as a prognostic predictor for heparin treatment in non-small cell lung cancer PMID: 25130770
    6. In this study, we demonstrate a previously unknown role for HCII in host defense. PMID: 23656734
    7. HCII potentiates the activation of vascular endothelial cells and the promotion of angiogenesis in response to hindlimb ischemia via an AMPK-eNOS signaling pathway. PMID: 22904320
    8. Plasma heparin cofactor II activity was independently and inversely associated with the development of cardiac remodeling, including cardiac concentric change, left atrial enlargement and left ventricular diastolic dysfunction. PMID: 21107326
    9. [REVIEW]HCII protects against vascular remodeling, including atherosclerosis PMID: 20671370
    10. potential for oversulfated disaccharides in controlling HCII-regulated thrombin generation PMID: 20053992
    11. Aspartic acid residues 72 and 75 and tyrosine-sulfate 73 of heparin cofactor II promote PMID: 11856753
    12. role of basic amino acids of the A helix of heparin cofactor II in heparin- or dermatan sulfate-mediated thrombin inhibition. PMID: 12095635
    13. Altering heparin cofactor II at VAL439 (P6) either impairs inhibition of thrombin or confers elastase resistance. PMID: 12152684
    14. The interactions of HCII with various heparins in solution competition experiments using SPR show that while calcium enhances this interaction, the activity of heparin-HCII complex against thrombin is not calcium dependent but can be enhanced by it. PMID: 15247982
    15. An asymptomatic Glu428Lys mutation affecting a conserved glutamate at the hinge (P17) of the reactive loop confirms the key structural role of the P17 glutamate in serpins. PMID: 15337701
    16. after receiving stent for peripheral artery disease, patients with a high HCII activity had a 0.39-fold reduced risk for instent restenosis PMID: 15543340
    17. HCII activity increases during pregnancy, and HCII levels are significantly decreased in women with severe pre-eclampsia. PMID: 16339402
    18. Plasma heparin cofactor II activity is an independent predictor of future cardiovascular events in patients after acute myocardial infarction. PMID: 18971786
    19. These results suggest that HCII is in a position to inhibit thrombin in atherosclerotic lesions where thrombin can exert a proatherogenic inflammatory response. PMID: 19747479

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  • 相关疾病：
    Thrombophilia due to heparin cofactor 2 deficiency (THPH10)
  • 蛋白家族：
    Serpin family
  • 组织特异性：
    Expressed predominantly in liver. Also present in plasma.
  • 数据库链接：

    HGNC: 4838

    OMIM: 142360

    KEGG: hsa:3053

    STRING: 9606.ENSP00000215727

    UniGene: Hs.474270