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SERPINB13 Antibody

  • 货号：
    CSB-PA021069GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9UIV8
  • 基因名：
    SERPINB13
  • 别名：
    HaCaT UV repressible serpin antibody; HaCaT UV-repressible serpin antibody; Headpin antibody; HSHUR7SEQ antibody; HUR7 antibody; Hurpin antibody; MGC126870 antibody; Peptidase inhibitor 13 antibody; PI-13 antibody; PI13 antibody; Protease inhibitor 13 antibody; Proteinase inhibitor 13 antibody; Serine (or cysteine) proteinase inhibitor clade B (ovalbumin) member 13 antibody; Serpin B13 antibody; Serpin peptidase inhibitor clade B (ovalbumin) member 13 antibody; SERPINB13 antibody; SPB13_HUMAN antibody; UV B repressed sequence HUR 7 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human SERPINB13
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May play a role in the proliferation or differentiation of keratinocytes.
  • 基因功能参考文献：
    1. clade B serpins help to maintain homeostasis by inducing protective humoral immunity PMID: 22593614
    2. These data demonstrate that RUNX1 is an important regulator of SERPINB13 and cathepsin K activity. PMID: 21723253
    3. A novel member of the serine proteinase inhibitor (Serpin) gene family that was originally cloned from a keratinocyte cDNA library. It has specificity for inhibiting lysosomal cysteine proteinases. PMID: 12504904
    4. Hurpin is a selective inhibitor of lysosomal cathepsin L and protects keratinocytes from ultraviolet-induced apoptosis. PMID: 12809493
    5. hurpin is expressed in skin and has a possible role in inflammatory processes or the regulation of endogenous or pathogen-derived proteinase activity PMID: 15885077
    6. Down-regulation of SERPINB13 is associated with head and neck squamous cell carcinoma PMID: 16357159
    7. the expression of hurpin was confined mainly to the basal layer in normal skin samples, whereas hurpin was overexpressed and redistributed in diseased skin PMID: 16433682
    8. Downregulation of SERPINB13 protein expression in HNSCC is positively associated with poor clinical outcome. Therefore, SERPINB13 seems to act as an important protease inhibitor involved in the progression of HNSCC. PMID: 19569240

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Serpin family, Ov-serpin subfamily
  • 组织特异性：
    Skin specific.
  • 数据库链接：

    HGNC: 8944

    OMIM: 604445

    KEGG: hsa:5275

    STRING: 9606.ENSP00000341584

    UniGene: Hs.241407