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SEPSECS Antibody

  • 货号：
    CSB-PA14389A0Rb
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: SEPSECS antibody at 2µg/ml + 293T whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 56, 6 kDa
      Observed band size: 56 kDa
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA14389A0Rb at dilution of 1:100
    • Immunofluorescent analysis of PC-3 cells using CSB-PA14389A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SEPSECS Polyclonal antibody
  • Uniprot No.：
    Q9HD40
  • 基因名：
  • 别名：
    DKFZp434B1417 antibody; Liver pancreas antigen antibody; Liver-pancreas antigen antibody; LP antibody; MGC161491 antibody; O phosphoseryl tRNA(Sec) selenium transferase antibody; O-phosphoseryl-tRNA(Sec) selenium transferase antibody; Sec synthase antibody; Selenocysteine synthase antibody; Selenocysteinyl tRNA(Sec) synthase antibody; Selenocysteinyl-tRNA(Sec) synthase antibody; Sep (O phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase antibody; Sep tRNA:Sec tRNA synthase antibody; Sep-tRNA:Sec-tRNA synthase antibody; SepSecS antibody; SLA antibody; SLA p35 antibody; SLA-p35 antibody; SLA/LP antibody; SLA/LP autoantigen antibody; Soluble liver antigen antibody; Soluble liver antigen/liver pancreas antigen antibody; Soluble Liver/Pancreas Antigen antibody; SPCS_HUMAN antibody; tRNA(Ser/Sec) associated antigenic protein antibody; tRNA(Ser/Sec)-associated antigenic protein antibody; TRNP48 antibody; UGA suppressor tRNA associated protein antibody; UGA suppressor tRNA-associated protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human O-phosphoseryl-tRNA(Sec) selenium transferase protein (5-451AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SEPSECS Antibody (CSB-PA14389A0Rb)，的标记方式是Non-conjugated。对于SEPSECS Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA14389B0Rb SEPSECS Antibody, HRP conjugated ELISA
    FITC CSB-PA14389C0Rb SEPSECS Antibody, FITC conjugated
    Biotin CSB-PA14389D0Rb SEPSECS Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
  • 基因功能参考文献：
    1. Structural basis for early-onset neurological disorders caused by mutations in human selenocysteine synthase has been described. PMID: 27576344
    2. Epileptic encephalopathy with burst suppression without brain malformations is associated with pathogenic variation in SEPSECS. PMID: 28133863
    3. The progression of clinical symptoms in these families is evidently slower than in previously reported cases, and the cerebellar atrophy milder by brain MRI, indicating that SEPSECS mutations are also involved in milder late-onset cerebellar atrophy. PMID: 26888482
    4. results suggest SEPSECS as a candidate gene for progressive encephalopathies with lactate elevation. PMID: 26115735
    5. structural analysis of the terminal catalytic complex in selenocysteine synthesis PMID: 25190812
    6. Data suggest SEPSECS silencing in placental trophoblasts inhibits proliferation, induces apoptosis, and reduces production of progesterone/chorionic gonadotropin (P/hCG); SEPSECS over-expression promotes cell proliferation and secretion of P/hCG. PMID: 23966103
    7. The human SepSecS protein is also known as soluble liver antigen/liver pancreas (SLA/LP), which represents one of the antigens of autoimmune hepatitis. PMID: 20623998
    8. SepSecS mutations cause autosomal-recessive progressive cerebellocerebral atrophy in Jews of Iraqi and Moroccan ancestry. PMID: 20920667
    9. detectable in liver extracts of autoimmune hepatitis patients' cells as the major autoantigenic component PMID: 19683415
    10. crystal structure of tRNA(Sec) in complex with SepSecS, phosphoserine, and thiophosphate, together with in vivo and in vitro enzyme assays, supports a pyridoxal phosphate-dependent mechanism of Sec-tRNA(Sec) formation PMID: 19608919

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  • 相关疾病：
    Pontocerebellar hypoplasia 2D (PCH2D)
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    SepSecS family
  • 组织特异性：
    Primarily expressed in liver, pancreas, kidney and lung. Overexpressed in PHA-stimulated T-cells.
  • 数据库链接：

    HGNC: 30605

    OMIM: 613009

    KEGG: hsa:51091

    STRING: 9606.ENSP00000371535

    UniGene: Hs.253305