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SENP7 Antibody

  • 货号：
    CSB-PA805340LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA805340LA01HU diluted at 1:500 and staining in paraffin-embedded human melanoma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SENP7 Polyclonal antibody
  • Uniprot No.：
    Q9BQF6
  • 基因名：
    SENP7
  • 别名：
    KIAA1707 antibody; Senp7 antibody; SENP7_HUMAN antibody; Sentrin specific protease antibody; Sentrin-specific protease 7 antibody; Sentrin/SUMO-specific protease SENP7 antibody; SSP2 antibody; SUMO 1 specific protease 2 antibody; SUMO specific protease antibody; SUMO-1-specific protease 2 antibody; SUMO1/sentrin specific peptidase 7 antibody; SUSP2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Sentrin-specific protease 7 protein (128-366AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SENP7 Antibody (CSB-PA805340LA01HU)，的标记方式是Non-conjugated。对于SENP7 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA805340LB01HU SENP7 Antibody, HRP conjugated ELISA
    FITC CSB-PA805340LC01HU SENP7 Antibody, FITC conjugated
    Biotin CSB-PA805340LD01HU SENP7 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:500-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO proteins to their mature forms.
  • 基因功能参考文献：
    1. SPOP inhibits hepatocellular carcinoma (HCC) cell metastasis via ubiquitin-dependent SENP7 proteolysis and may thus serve as a new opinion for the prevention of HCC metastasis. PMID: 29777712
    2. c-Myc is targeted to the proteasome for degradation in a SUMOylation-dependent manner, regulated by PIAS1, SENP7 and RNF4 PMID: 25895136
    3. deSUMOylation by SENP7 is required to promote a permissive chromatin environment for DNA repair. PMID: 24018422
    4. differential splicing of the SENP7 regulates either tumor suppression or progression PMID: 23045645
    5. Loop 1 insertion in SENP6 and SENP7 as a platform to discriminate between SUMO1 and SUMO2/3 isoforms in this subclass of the SUMO protease family. PMID: 21878624
    6. SENP6 and SENP7 exhibit lower rates for processing pre-SUMO1, pre-SUMO2, or pre-SUMO3 in comparison with SENP2 PMID: 18799455

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  • 蛋白家族：
    Peptidase C48 family
  • 数据库链接：

    HGNC: 30402

    OMIM: 612846

    KEGG: hsa:57337

    STRING: 9606.ENSP00000377655

    UniGene: Hs.529551