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SENP5 Antibody

  • 货号：
    CSB-PA004063
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of COS7 cells using SENP5 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q96HI0
  • 基因名：
    SENP5
  • 别名：
    FKSG45 antibody; FLJ42398 antibody; MGC27076 antibody; Protease FKSG45 antibody; SENP5 antibody; SENP5_HUMAN antibody; Sentrin specific protease SENP5 antibody; Sentrin-specific protease 5 antibody; Sentrin/SUMO specific protease SENP5 antibody; Sentrin/SUMO-specific protease SENP5 antibody; SUMO specific protease SENP5 antibody; SUMO1/sentrin specific peptidase 5 antibody; SUMO1/sentrin specific protease 5 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Monkey
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human SENP5.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division.
  • 基因功能参考文献：
    1. Results from a study on gene expression variability markers in early-stage human embryos shows that SENP5 is a putative expression variability marker for the 3-day, 8-cell embryo stage. PMID: 26288249
    2. Mild oxidative stress stabilized the SENP5 protein in the oral squamous cell carcinoma cells, and only the combination of SENP5 silencing and H2O2 application led to mitochondria fragmentation and a significant increase in cell apoptosis. PMID: 25901414
    3. Low expression of SENP5 is associated with good prognosis among breast cancer patients. PMID: 24658161
    4. Knockdown of SENP5 resulted in increased levels of SUMO-1 and SUMO-2/3, inhibition of cell proliferation, defects in nuclear morphology, and appearance of binucleate cells, revealing an essential role for SENP5 in mitosis and/or cytokinesis. PMID: 16738315
    5. altered subcellular localization of SENP5 in oral squamous cell carcinoma (OSCC) cells and the correlation between SENP5 expression and the differentiation of OSCC. PMID: 18949399
    6. Nucleolar protein B23/nucleophosmin regulates the vertebrate SUMO pathway through SENP3 and SENP5 proteases. PMID: 19015314

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  • 亚细胞定位：
    Nucleus, nucleolus.
  • 蛋白家族：
    Peptidase C48 family
  • 数据库链接：

    HGNC: 28407

    OMIM: 612845

    KEGG: hsa:205564

    STRING: 9606.ENSP00000327197

    UniGene: Hs.240770