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SEMA6B Antibody

  • 货号：
    CSB-PA862010LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA862010LA01HU diluted at 1:100 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of Hela cells with CSB-PA862010LA01HU at 1:33, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SEMA6B Polyclonal antibody
  • Uniprot No.：
    Q9H3T3
  • 基因名：
    SEMA6B
  • 别名：
    SEM-SEMA-Y antibody; SEM6B_HUMAN antibody; sema domain; transmembrane domain (TM); and cytoplasmic domain; (semaphorin) 6B antibody; Sema Z antibody; SEMA-VIB antibody; Sema6b antibody; SEMAN antibody; semaphorin VIB antibody; Semaphorin-6B antibody; semaphorin-6Ba antibody; Semaphorin-Z antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Semaphorin-6B protein (756-888AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SEMA6B Antibody (CSB-PA862010LA01HU)，的标记方式是Non-conjugated。对于SEMA6B Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA862010LB01HU SEMA6B Antibody, HRP conjugated ELISA
    FITC CSB-PA862010LC01HU SEMA6B Antibody, FITC conjugated
    Biotin CSB-PA862010LD01HU SEMA6B Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Functions as a cell surface repellent for mossy fibers of developping neurons in the hippocampus where it plays a role in axon guidance. May function through the PLXNA4 receptor expressed by mossy cell axons.; (Microbial infection) Acts as a receptor for P.sordellii toxin TcsL in the in the vascular endothelium.
  • 基因功能参考文献：
    1. Semaphorin 6B is related to tumour differentiation and metastasis in vivo, and tumour cell migration, adhesion and invasion in vitro. PMID: 23781008
    2. states a clear relation among breast cancer and SEMA6B expression; moreover we describe for the first time the SEMA6Ba protein and report here the analysis of SEMA6Ba RNA messenger, the protein expression and the cellular localization PMID: 23665584
    3. Gene SEMA6B is strongly down regulated by peroxisome proliferator-activated receptors. PMID: 15177567
  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Semaphorin family
  • 组织特异性：
    Expressed in the brain in GABAergic neurons.
  • 数据库链接：

    HGNC: 10739

    OMIM: 608873

    KEGG: hsa:10501

    STRING: 9606.ENSP00000301293

    UniGene: Hs.465642