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  4. SEC13 Antibody

SEC13 Antibody

  • 货号：
    CSB-PA020934GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P55735
  • 基因名：
  • 别名：
    D3S1231E antibody; Npp 20 antibody; Npp20 antibody; Protein SEC13 homolog antibody; SEC13 (S. cerevisiae) like 1 antibody; Sec13 antibody; SEC13 homolog (S. cerevisiae) antibody; SEC13 homolog antibody; SEC13 like 1 (S. cerevisiae) antibody; SEC13 like 1 isoform antibody; SEC13 like protein 1 antibody; SEC13 protein antibody; SEC13 related protein antibody; SEC13-like protein 1 antibody; SEC13-related protein antibody; SEC13_HUMAN antibody; SEC13R antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human SEC13
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles. Required for the exit of adipsin (CFD/ADN), an adipocyte-secreted protein from the endoplasmic reticulum.; As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1.
  • 基因功能参考文献：
    1. TRAPPC12, but not TRAPPC8, bound to Sec13/Sec31A tetramer but each Sec protein alone could not interact with TRAPPC12. PMID: 28240221
    2. we demonstrated Sec13 as a novel component that was involved in VISA-mediated antiviral signaling pathway. PMID: 29948782
    3. GNL2 and SEC13 are required for nonsense-mediated mRNA decay pathway in human cells. PMID: 25452588
    4. When embedded in a three-dimensional matrix, Sec13-depleted Caco-2 cells form cysts but, unlike controls, are defective in lumen expansion. PMID: 22331354
    5. three-dimensional reconstruction of Sec13/31 cages at 30 A resolution using cryo-electron microscopy and single particle analysis PMID: 16407955
    6. Determine crystal structure of Sec13-Nup145C dimer. PMID: 18160040
    7. Data show that coupling of the Sec23/24 and Sec13/31 layers of the COPII coat is required to drive export of collagen from the endoplasmic reticulum, and that efficient COPII assembly is essential for normal craniofacial development during embryogenesis. PMID: 18713835

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  • 亚细胞定位：
    Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus, nuclear pore complex. Lysosome membrane.
  • 蛋白家族：
    WD repeat SEC13 family
  • 数据库链接：

    HGNC: 10697

    OMIM: 600152

    KEGG: hsa:6396

    STRING: 9606.ENSP00000312122

    UniGene: Hs.166924