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SCTR Antibody

  • 货号：
    CSB-PA020865LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Rat liver tissue
      All lanes: SCTR antibody at 2.5µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 51 kDa
      Observed band size: 51 kDa
    • Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA020865LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA020865LA01HU at dilution of 1:100
    • Immunofluorescent analysis of PC-3 cells using CSB-PA020865LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SCTR Polyclonal antibody
  • Uniprot No.：
    P47872
  • 基因名：
  • 别名：
    SCTR; Secretin receptor; SCT-R
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Rat
  • 免疫原：
    Recombinant Human Secretin receptor protein (51-135AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SCTR Antibody (CSB-PA020865LA01HU)，的标记方式是Non-conjugated。对于SCTR Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA020865LB01HU SCTR Antibody, HRP conjugated ELISA
    FITC CSB-PA020865LC01HU SCTR Antibody, FITC conjugated
    Biotin CSB-PA020865LD01HU SCTR Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Receptor for secretin (SCT), which is involved in different processes such as regulation of the pH of the duodenal content, food intake and water homeostasis. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Upon binding to secretin, regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas. In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation. Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation. Also able to stimulate lipolysis in white adipocytes. Also plays an important role in cellular osmoregulation by regulating renal water reabsorption. Also plays a role in the central nervous system: required for synaptic plasticity.
  • 基因功能参考文献：
    1. elevated in primary sclerosing cholangitis liver samples compared to healthy controls PMID: 27115285
    2. Structure and Function of Cross-class Complexes of G Protein-coupled Secretin and Angiotensin 1a Receptors. PMID: 27330080
    3. Cysteine trapping identified charge-charge interactions between secretin and secretin receptor residues in TM5, TM6, ECL2, and ECL3 domains. PMID: 26740626
    4. Our findings indicate that SCTR suppresses the proliferation of normal breast cells, while the gene stimulates the proliferation and migration of cancer cells being downregulated by promoter methylation. PMID: 26397240
    5. High SCTR expression is associated with liver metastases of pancreas neuroendocrine tumors. PMID: 25241033
    6. Results suggest that Secretin is a potent modulator of adipocyte functions, demonstrating overall a role in enhanced substrate cycling. PMID: 22565418
    7. Taken together, we propose here that the down-regulatory effects of NRSF on hSCTR gene expression are mediated via its suppression on Sp1-mediated transactivation. PMID: 23168245
    8. results demonstrate that secretin and/or the modulation of SCTR expression might have potential as a therapeutic tool in the treatment of cholangiocarcinoma PMID: 19904746
    9. Increasing expression of secretin receptor competes for receptor modifying protein 3 (RAMP3) association with calcitonin receptor-like receptor (CLR) to yield a functional adrenomedullin receptor. PMID: 19886671
    10. promoter methylation plays a role in the regulation of SR gene expression. PMID: 14645499
    11. Secretin receptor transcripts are present in Purkinje cells and basket cells in the molecular cell layer of human cerebellum. PMID: 15706223
    12. There is a marked reduction in SCTR binding in ductal neoplasia. PMID: 16192632
    13. Secretin receptor oligomerization occurs through -GxxxG- motif-independent interactions of transmembrane segments during the maturation of nascent molecules. PMID: 16819820
    14. The high receptor expression in cholangiocarcinomas may be used for in vivo secretin receptor-targeting of these tumors and for the differential diagnosis with hepatocellular carcinoma. PMID: 16935383
    15. A novel abnormal spliceoform of the secretin receptor was identified in pancreatic and bile duct cancers and developed as a dual antibody sandwich enzyme-linked immunosorbent assay for measure in the circulation. PMID: 17678920
    16. Secretin-receptor and secretin-receptor-variant expressions occur in all gastrinomas PMID: 17711922
    17. secretin receptors are new markers for bronchopulmonary carcinoid tumors PMID: 18223557
    18. Data show that Family B G-protein-coupled receptor oligomerization occurs, with many structurally related members, such as the secretin receptor,associating with each other. PMID: 18401761
    19. These results suggest that the secretin receptor can exist only as a structurally-specific homo-dimer, without being present as higher-order oligomers. PMID: 18680717

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 2 family
  • 数据库链接：

    HGNC: 10608

    OMIM: 182098

    KEGG: hsa:6344

    STRING: 9606.ENSP00000019103

    UniGene: Hs.42091