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SCNN1G Antibody

  • 货号：
    CSB-PA004639
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of A549 cells using ENaC γ Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    P51170
  • 基因名：
    SCNN1G
  • 别名：
    Amiloride sensitive epithelial sodium channel gamma subunit antibody; Amiloride sensitive sodium channel subunit gamma antibody; Amiloride-sensitive sodium channel subunit gamma antibody; BESC3 antibody; ENaC gamma subunit antibody; ENaCG antibody; ENaCgamma antibody; Epithelial Na(+) channel subunit gamma antibody; Epithelial Na+ channel subunit gamma antibody; Gamma ENaC antibody; Gamma NaCH antibody; Gamma-ENaC antibody; Gamma-NaCH antibody; Nonvoltage gated sodium channel 1 subunit gamma antibody; Nonvoltage-gated sodium channel 1 subunit gamma antibody; PHA 1 antibody; PHA1 antibody; SCNEG antibody; SCNN 1G antibody; SCNN1G antibody; SCNNG_HUMAN antibody; Sodium channel epithelial 1 gamma subunit antibody; Sodium channel non voltage gated 1 gamma subunit antibody; Sodium channel nonvoltage gated 1 gamma antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human ENaC γ.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
  • 基因功能参考文献：
    1. One nonsynonymous amino acid variants in SCNN1G in nonwhite Cystic fibrosis patients with non-diagnostic CFTR genotypes was identified. PMID: 25900089
    2. Both vascular smooth muscle cell and bronchial gamma-ENaC downregulation may explain pulmonary fluid disturbances and participate in pulmonary edema pathogenesis. PMID: 26437894
    3. Suggest that SCNN1G gene has important roles in blood pressure regulation in the Han Chinese population. PMID: 25231509
    4. Data indicate that urokinase-type plasminogen activator (uPA) activates epithelial sodium channel, gamma subunit (ENaC gamma) through catalytic activity-dependent proteolytic modification. PMID: 25555911
    5. High serum leptin may reduce endometrial receptivity by activating the STAT3 signal pathway and down-regulating gamma-ENaC expression in the endometrium. PMID: 25450293
    6. human kidney gammaENaC is subject to proteolytic cleavage, yielding fragments compatible with furin cleavage, and proteinuria is associated with cleavage at the putative prostasin/kallikrein site and removal of the inhibitory tract within gammaENaC PMID: 25060057
    7. gamma subunit palmitoylation has a dominant role over beta subunit palmitoylation in modulating ENaC gating PMID: 24692558
    8. These results suggest that the mutant gammaL511Q enhances ENaC activity by increasing channel open probability and dampens channel regulation by extracellular Na(+) and proteases. PMID: 23136006
    9. Mutating two valine residues (V182 and V193) in the critical region of gammaENaC prevented proteolytic activation of ENaC by Cat-S. PMID: 22864553
    10. All four ENaC subunits (alphabetagammadelta) are expressed in the normal human eye, with distinct localization of subunits possibly reflecting different functional states of the channel. PMID: 22167092
    11. variants of ENaC subunits may contribute to the variation of BP response to dietary sodium intake PMID: 21562341
    12. The intronic single-nucleotide polymorphism of SCNN1G (rs13331086) was significantly positively associated with higher blood pressure and urinary potassium excretion in 4 white European cohorts. PMID: 22006290
    13. Demonstrate that the metalloprotease meprin beta and gamma-ENaC associate directly through cytoplasmic domains. PMID: 20953144
    14. A new nonsense mutation(Q567X) of the SCNN1G gene is likely the cause of Liddle's syndrome in family 2. PMID: 20376790
    15. Novel mutations responsible for autosomal recessive multisystem pseudohypoaldosteronism and sequence variants in epithelial sodium channel gamma-subunit gene. PMID: 12107247
    16. GammaENaC Asn530Ser mutation increases channel open probability and is consistent with abnormally high sodium reabsorption in distal nephron. First mutation in extracellular domain of ENaC subunit with increased ENaC activity and Liddle's syndrome. PMID: 12473862
    17. Not only are CFTR and ENaC activated together in duct salt absorption, but ENaC activation depends on functioning CFTR. PMID: 12548396
    18. Common variants of the ENaC gamma subunit confer susceptibility to human essential hypertension. PMID: 15661075
    19. We conclude that overexpression of ClC-5, specifically amino acids 347-647, can alter the normal translation or trafficking of ENaC and other ion transport proteins by a mechanism that is independent of the chloride conductance of ClC-5. PMID: 15702377
    20. SCNN1G is a modulator in Cystic Fibrosis. PMID: 16463024
    21. 14-3-3 inhibits the interaction between the WW domains of hNedd4-2 and the PY motif of the epithelial Na(+) channel, ENaC PMID: 16716084
    22. A synthetic peptide corresponding to the fragment cleaved from the gamma subunit is a reversible inhibitor of endogenous ENaCs in cells; results suggest that multiple proteases cleave ENaC gamma subunits to fully activate the channel. PMID: 17199078
    23. genetic variants in ENaCgamma (epithelial sodium channel gamma) genes do not modulate disease severity in the majority of CF patients PMID: 17560176
    24. Relatively common polymorphisms in the SCNN1G gene are associated with high systolic blood pressure in the general Australian white population. PMID: 17698725
    25. protease binding and perhaps cleavage of the gamma subunit results in ENaC activation PMID: 17998393
    26. Plasmin activates epithelial Na+ channels by cleaving the gamma subunit PMID: 18981180
    27. Plasmin in nephrotic urine activates the epithelial sodium channel PMID: 19073825

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  • 相关疾病：
    Liddle syndrome (LIDLS); Bronchiectasis with or without elevated sweat chloride 3 (BESC3)
  • 亚细胞定位：
    Apical cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Amiloride-sensitive sodium channel (TC 1.A.6) family, SCNN1G subfamily
  • 组织特异性：
    Expressed in kidney (at protein level).
  • 数据库链接：

    HGNC: 10602

    OMIM: 177200

    KEGG: hsa:6340

    STRING: 9606.ENSP00000300061

    UniGene: Hs.371727