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SCNN1D Antibody

  • 货号：
    CSB-PA989132
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from RAW264.7 cells, using SCNN1D antibody.
    • Immunofluorescence analysis of A549 cells, using SCNN1D antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SCNN1D Polyclonal antibody
  • Uniprot No.：
    P51172
  • 基因名：
    SCNN1D
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from internal of Human SCNN1D.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
    IF 1:100-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
  • 基因功能参考文献：
    1. delta-ENaC expression is low in NCI-H441, Calu-3, and ATI cells and does not contribute to transepithelial sodium absorption PMID: 25677639
    2. study characterized a new variant, delta2 ENaC, in lung epithelial cells; heterologous delta2betagamma ENaC exhibited a number of divergent features from the delta1betagamma counterpart in biophysics and pharmacology, regulation, and the lifespan of proteins PMID: 22505667
    3. delta-ENaC undergoes dynamin-independent endocytosis as opposed to alphabetagamma-channels. PMID: 22159085
    4. These results suggest that COMMD1 downregulates deltaENaC activity by reducing deltaENaC surface expression through promoting internalization of surface deltaENaC to an intracellular recycling pool, possibly via enhanced ubiquitination. PMID: 21741370
    5. Cpt-cAMP activates human epithelial sodium channels via relieving self-inhibition. PMID: 21419751
    6. CPT-cGMP Stimulates Human Alveolar Fluid Clearance by Releasing External Na+ Self-Inhibition of ENaC. PMID: 21562313
    7. Data support a physiological role for SGK1.1 in the regulation of delta-ENaC through a pathway that differs from the classical one and suggest that the kinase could serve as an integrator of different signaling pathways converging on the channel. PMID: 20631247
    8. delta ENaC is regulated by Murr1 PMID: 14645214
    9. ENaCdelta activity is regulated by protons, and may contribute to the pH sensation and/or pH regulation in the human brain PMID: 14726523
    10. ENaCdelta is chemically activated by capsazepine by a proton-dependent mechanism PMID: 15308635
    11. analysis of anovel spliced variant of the ENaC delta-subunit in the human brain PMID: 16930535
    12. ENaC delta isoforms are widely expressed in pyramidal cells of the human and monkey cerebral cortex and in different neuronal populations of telencephalic subcortical nuclei. PMID: 17472699
    13. Expression analyses at the level of mRNA clearly revealed that ENaC delta transcript was strongly expressed in human melanoma cells using reverse transcription-polymerase chain reaction and cell-based in situ hybridization techniques. PMID: 18073141
    14. ENaCdelta is a candidate molecule for pH sensing in the gastrointestinal system in humans, providing a novel therapeutic target for gastro-oesophageal reflux disease PMID: 18951889
    15. the delta-subunit of ENaC alters proteolytic channel activation and enhances base-line channel activity PMID: 19717556
    16. delta ENaC is a proton sensor PMID: 15084585

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Amiloride-sensitive sodium channel (TC 1.A.6) family, SCNN1D subfamily
  • 数据库链接：

    HGNC: 10601

    OMIM: 601328

    KEGG: hsa:6339

    STRING: 9606.ENSP00000368411

    UniGene: Hs.512681