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SCN4B Antibody

  • 货号：
    CSB-PA818246LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of HepG2 cells with CSB-PA818246LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SCN4B Polyclonal antibody
  • Uniprot No.：
    Q8IWT1
  • 基因名：
    SCN4B
  • 别名：
    SCN4B antibody; Sodium channel subunit beta-4 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Sodium channel subunit beta-4 protein (31-162AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SCN4B Antibody (CSB-PA818246LA01HU)，的标记方式是Non-conjugated。对于SCN4B Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA818246LB01HU SCN4B Antibody, HRP conjugated ELISA
    FITC CSB-PA818246LC01HU SCN4B Antibody, FITC conjugated
    Biotin CSB-PA818246LD01HU SCN4B Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the susceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom.
  • 基因功能参考文献：
    1. SCN4B overexpression reduces cancer cell invasiveness and tumour progression. PMID: 27917859
    2. Preserved SCN4B expression is an independent indicator of favorable recurrence-free survival in classical papillary thyroid cancer. PMID: 29723302
    3. Data suggest that extracellular domains of SCN4B directly interact with each other in parallel homodimers that involve an intermolecular disulfide bond between unpaired Cys residues (Cys58) in loop connecting strands B and C and intermolecular hydrophobic and hydrogen-bonding interactions of N-terminal segments (Ser30-Val35); SCN4B homodimers appear to play role in cell-cell adhesion. PMID: 28655765
    4. The expression of a human-specific isoform of the voltage-gated sodium channel subunit SCN4B was significantly correlated to lifetime alcohol consumption PMID: 25450227
    5. results suggest the presence of a docking site that is maintained by a cysteine bridge buried within the hydrophobic core of beta4. PMID: 24297919
    6. this is the first study to demonstrate an association of SCN4B mutations with AF, suggesting SCN4B as a novel AF susceptibility gene. PMID: 23604097
    7. SCN5A-SCN4B were found to be essential for positive selection of CD4(+) T cells. PMID: 22842345
    8. The researchers found evidence of an association between SCN4B subunit mutations and sudden infant death syndrome pathogenesis. PMID: 20226894
    9. The paroxysmal extreme pain disorder associated Nav1.7 missense mutations M1627K, T1464I and V1299F increase Navbeta4 peptide-mediated resurgent sodium currents, in contrast to the erythromelalgia associated I848T and L858H Nav1.7 missense mutations. PMID: 21115638
    10. molecular cloning and characterization of sodium channel beta4 PMID: 12930796
    11. SCN4B is a long QT syndrome susceptibility gene. PMID: 17592081
    12. Co-expression of the beta1 subunit impeded slow inactivation elicited by a 30-s depolarization, such that the voltage dependence was right shifted (depolarized) and recovery was hastened. PMID: 18941776

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  • 相关疾病：
    Long QT syndrome 10 (LQT10); Atrial fibrillation, familial, 17 (ATFB17)
  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Sodium channel auxiliary subunit SCN4B (TC 8.A.17) family
  • 组织特异性：
    Expressed at a high level in dorsal root ganglia, at a lower level in brain, spinal cord, skeletal muscle and heart. Expressed in the atrium.
  • 数据库链接：

    HGNC: 10592

    OMIM: 608256

    KEGG: hsa:6330

    STRING: 9606.ENSP00000322460

    UniGene: Hs.65239