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SCN11A Antibody

  • 货号：
    CSB-PA961122
  • 规格：
    ￥2024
  • 图片：
    • Immunohistochemical analysis of paraffin-embedded Human cervical cancer tissue using at dilution 1/40.
    • Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue using at dilution 1/40.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SCN11A Polyclonal antibody
  • Uniprot No.：
    Q9UI33
  • 基因名：
    SCN11A
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide corresponding to a region derived from internal residues of Human sodium channel, voltage-gated, type XI, alpha subunit
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:50-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization.
  • 基因功能参考文献：
    1. We identified a missense mutation of p.Arg225Cys in SCN11A in a four-generation Chinese family with early-onset familial episodic pain and adult onset familial essential tremor syndrome. PMID: 28298626
    2. SCN11A single-nucleotide polymorphisms affect Postoperative pain sensitivity in Chinese Han women after Gynecological surgery. The SNP rs33985936 and rs13080116 may serve as novel predictors for Postoperative pain. PMID: 28953656
    3. a U-shaped relationship between the resting potential and the neuronal action potential threshold explains why NaV1.9 mutations that evoke small degrees of membrane depolarization cause hyperexcitability and familial episodic pain disorder or painful neuropathy, while mutations evoking larger membrane depolarizations cause hypoexcitability and insensitivity to pain. PMID: 28530638
    4. Recently Nav1.9, a voltage-gated sodium channel subtype, has been established as a genetic influence for certain peripheral pain syndromes. PMID: 27224030
    5. Results show the expression of Nav1.9 channels within the human colon for the first time. Furthermore, Nav1.9 channel expression is decreased in Hirschsprung's disease versus normal controls. PMID: 27297039
    6. autosomal dominant Congenital insensitivity to pain reflects the second gain-of-function mutation of SCN11A. PMID: 26746779
    7. A missense mutation (p.V1184A) in NaV1.9 leads to cold-aggravated peripheral pain. PMID: 26645915
    8. A G699R substitution in the Nav1.9 domain II S4-S5 linker renders dorsal root ganglion neurons hyperexcitable, via depolarized resting membrane potential, reduced current threshold and increased evoked firing in small-fiber neuropathy. PMID: 25791876
    9. missense mutations of Nav1.9 in individuals with painful peripheral neuropathy PMID: 24776970
    10. The results demonstrate that Nav1.8 and Nav1.9 are present in human lingual nerve neuromas, with significant correlations between the level of expression of Nav1.8 and symptoms of pain. PMID: 24144460
    11. we identified a specific de novo missense mutation in SCN11A in individuals with the congenital inability to experience pain who suffer from recurrent tissue damage and severe mutilations. PMID: 24036948
    12. Gain-of-function mutations in SCN11A can be causative of an autosomal-dominant episodic pain disorder. PMID: 24207120
    13. Results provide evidence that Nav1.9 plays a crucial role in the generation of heat and mechanical pain hypersensitivity, both in subacute and chronic inflammatory pain models. PMID: 21857998
    14. we demonstrate that the tetrodotoxin-insensitive sodium channel Na(V)1.9 underlies the neurotrophin-evoked excitation PMID: 12384689

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  • 相关疾病：
    Neuropathy, hereditary sensory and autonomic, 7 (HSAN7); Episodic pain syndrome, familial, 3 (FEPS3)
  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Sodium channel (TC 1.A.1.10) family, Nav1.9/SCN11A subfamily
  • 组织特异性：
    Expressed in the dorsal root ganglia and trigeminal ganglia, olfactory bulb, hippocampus, cerebellar cortex, spinal cord, spleen, small intestine and placenta.
  • 数据库链接：

    HGNC: 10583

    OMIM: 604385

    KEGG: hsa:11280

    STRING: 9606.ENSP00000307599

    UniGene: Hs.591657