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SCG3 Antibody

  • 货号：
    CSB-PA004877
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of mouse heart mouse kidney cells using Sg III Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q8WXD2
  • 基因名：
    SCG3
  • 别名：
    1B1075 antibody; AI385542 antibody; Chgd antibody; SCG3 antibody; SCG3_HUMAN antibody; Secretogranin III antibody; Secretogranin-3 antibody; SGCG antibody; SgIII antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Rat
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human Sg III.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Member of the granin protein family that regulates the biogenesis of secretory granules. Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA. May also play a role in angiogenesis. Promotes endothelial proliferation, migration and tube formation through MEK/ERK signaling pathway.
  • 基因功能参考文献：
    1. This review summarizes our current knowledge of Scg3 as a regulatory protein of secretory granules, highlights its new role as a highly disease-selective angiogenic factor, and envisions Scg3 inhibitors as "selective angiogenesis blockers" for targeted therapy of diabetic retinopathy. [review] PMID: 28856381
    2. results suggested an association between the fucosylated glycoform of short-form SgIII and Small Cell Lung Carcinoma PMID: 28949141
    3. SCG3 is essential in the process and targeting of neuropeptides and neurotrophins, its participation in the pathological progression of Alzheimer's disease may be suggested PMID: 22998035
    4. SCG3 may be involved in apoptosis signal transduction as a caspase substrate.It may be a pivotal component of the neuroendocrine pathway & play an important role in neuronal communication & neurotransmitter release. PMID: 22987761
    5. Our data suggest that genetic variations in the FTO, SCG3 and MTMR9 genes independently influence the risk of metabolic syndrome. PMID: 21796137
    6. This short review deals with investigations in neuroendocrine tumors (NETs) with antibodies against defined epitopes of chromogranins (Cgs) A and B and secretogranins (Sgs) II and III. PMID: 21046454
    7. SgIII was expressed in 41 of 47 neuroendocrine tumours. The expression of SgIII agreed well with that of CgA, CgB and SgII, with exceptions of phaeochromocytomas and parathyroid adenomas. PMID: 20550951
    8. Genetic variations in the SCG3 gene may influence the risk of obesity through possible regulation of hypothalamic neuropeptide secretion. PMID: 17200173
    9. Secretogranins III assays failed to detect increased concentrations in any of the patients with neuroendocrine tumours. PMID: 18448176

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  • 亚细胞定位：
    Cytoplasmic vesicle, secretory vesicle. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Secreted.
  • 组织特异性：
    Expressed in brain, heart, kidney, liver and skeletal muscle.
  • 数据库链接：

    HGNC: 13707

    OMIM: 611796

    KEGG: hsa:29106

    STRING: 9606.ENSP00000220478

    UniGene: Hs.232618