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SASH1 Antibody

  • 货号：
    CSB-PA020714LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA020714LA01HU diluted at 1:300 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SASH1 Polyclonal antibody
  • Uniprot No.：
    O94885
  • 基因名：
    SASH1
  • 别名：
    2500002E12Rik antibody; dJ323M4 antibody; dJ323M4.1 antibody; KIAA0790 antibody; PEPE 1 antibody; PEPE1 antibody; Proline glutamate repeat containing protein antibody; Proline-glutamate repeat-containing protein antibody; RP3 323M4.1 antibody; SAM and SH3 domain containing 1 antibody; SAM and SH3 domain containing protein 1 antibody; SAM and SH3 domain-containing protein 1 antibody; SASH 1 antibody; Sash1 antibody; SASH1_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human SAM and SH3 domain-containing protein 1 protein (76-191AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SASH1 Antibody (CSB-PA020714LA01HU)，的标记方式是Non-conjugated。对于SASH1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA020714LB01HU SASH1 Antibody, HRP conjugated ELISA
    FITC CSB-PA020714LC01HU SASH1 Antibody, FITC conjugated
    Biotin CSB-PA020714LD01HU SASH1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation. Regulates TRAF6 and MAP3K7 ubiquitination. Involved in the regulation of cell mobility. Regulates lipolysaccharide (LPS)-induced endothelial cell migration. Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis.
  • 基因功能参考文献：
    1. findings suggested that SASH1 can be useful as a new prognostic marker and therapeutic target in cervical cancer patients. PMID: 28975991
    2. Data show that SAM and SH3 domain containing 1 protein (SASH1) binds with mitogen-activated protein kinase kinase 2 (MAP2K2), and SASH1 mutations promote binding between SASH1 and MAP2K2. PMID: 28382689
    3. SASH1 is prognostic in breast cancer and could have subtype-dependent effects on breast cancer progression. PMID: 27637080
    4. SASH1 may inhibit hepatocarcinoma cell invasion and metastasis through down-regulating the Shh-Gli1 and PI3K-AKT pathways PMID: 28600143
    5. Case Report: SASH1 missense mutation in a Chinese Family with multiple lentigines. PMID: 27840890
    6. SASH1 acts through NOTCH1 and its inhibitor DLK1 in a three-dimensional model of lumenogenesis involving CEACAM1. PMID: 28823832
    7. SASH1 is cleaved by caspase-3 following Ultraviolet C-induced apoptosis. PMID: 27831555
    8. a novel p53/POMC/Galphas/SASH1 autoregulatory positive feedback loop is regulated by SASH1 mutations to induce pathological hyperpigmentation phenotype. PMID: 27885802
    9. Overexpression of SASH1 inhibits TGF-beta1-induced EMT. PMID: 27178818
    10. Overexpression of SASH1 suppressed the expression of Shh. PMID: 27178819
    11. The loss or inhibition of SASH1 expression may play an important role in thyroid cancer development, invasion, and metastasis. PMID: 26722413
    12. Two SNPs were significantly associated with rotator cuff tearing, residing in SAP30BP on chromosome 17 and SASH1 on chromosome 6. PMID: 26350878
    13. SASH1 expression is increased in atherosclerotic carotids in smokers and its silencing affects endothelial angiogenic functions PMID: 26318107
    14. SASH1 expression strongly correlated with glioma grades, showing higher expression at a lower grade. PMID: 26424902
    15. Data suggest that SASH1 (SAM and SH3 domain-containing protein 1) should be added to the list of genes responsible for autosomal-dominant and -recessive genodermatosis. PMID: 25315659
    16. SASH1 Is Involved in an Autosomal Dominant Lentiginous Phenotype. PMID: 26203640
    17. Propose that increase of DNA methylation level in the promoter region of gene SASH1, particularly CpG_26.27 or CpG_54.55 sites, possibly repressed SASH1 expression in breast cancer. PMID: 24344014
    18. The SASH1 gene is blocked cyclin B1-Cdc2 binding, either directly or indirectly, leading to G2/M arrest. PMID: 23023727
    19. SASH1 regulates IQGAP1-E-Cadherin signalling and crosstalking between GPCR signalling, calmodulin signalling for the modulation of melanocytes invasion. PMID: 23333244
    20. Overexpression of SASH1 might be associated with the inhibition of growth, proliferation, and invasion osteosarcoma cells. PMID: 23108792
    21. Loss of SASH1 is associated with glioma. PMID: 22915266
    22. The SASH1 gene may inhibit A549 cell growth and proliferation as well as promote cellular apoptosis. The overexpression of the SASH1 gene may also be related to the decreased migration of A549 human lung cancer cells. PMID: 22488244
    23. A mechanistic role for SASH1 in tumor formation by regulating the adhesive and migratory behavior of cancer cells has been shown. PMID: 21820526
    24. tumor suppressor gene possibly involved in tumorigenesis of breast and other solid cancers PMID: 12771949
    25. Downregulated expression of the candidate tumour suppressor gene SASH1 is associated with colon cancer PMID: 17088907

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  • 亚细胞定位：
    Cytoplasm.
  • 组织特异性：
    Expressed ubiquitously, with highest levels in lung, placenta, spleen and thymus. Down-regulated in the majority (74%) of breast tumors in comparison with corresponding normal breast epithelial tissues. Expressed in the epidermis, epidermal keratinocytes,
  • 数据库链接：

    HGNC: 19182

    OMIM: 607955

    KEGG: hsa:23328

    STRING: 9606.ENSP00000356437

    UniGene: Hs.193133