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SAMD9 Antibody

  • 中文名称：
    SAMD9兔多克隆抗体
  • 货号：
    CSB-PA775725
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA775725(SAMD9 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q5K651
  • 基因名：
    SAMD9
  • 别名：
    C7orf5 antibody; DRIF1 antibody; expressed in aggressive fibromatosis antibody; KIAA2004 antibody; NFTC antibody; OEF1 antibody; OEF2 antibody; SAM domain-containing protein 9 antibody; SAMD9 antibody; SAMD9_HUMAN antibody; sterile alpha motif domain containing 9 antibody; Sterile alpha motif domain-containing protein 9 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human SAMD9
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May play a role in the inflammatory response to tissue injury and the control of extra-osseous calcification, acting as a downstream target of TNF-alpha signaling. Involved in the regulation of EGR1, in coordination with RGL2. May be involved in endosome fusion.
  • 基因功能参考文献：
    1. In humans, both SAMD9 and SAMD9L are poxvirus restriction factors, although the latter requires interferon induction in many cell types. PMID: 29447249
    2. findings establish SAMD9/SAMD9L mutations as a new class of germline lesions with variable clinical phenotypes, including familial MDS PMID: 28487541
    3. Progressive loss of mutated SAMD9 through the development of monosomy 7 (-7), deletions of 7q (7q-), and secondary somatic loss-of-function (nonsense and frameshift) mutations in SAMD9 rescued the growth-restricting effects of mutant SAMD9 proteins in bone marrow and was associated with increased length of survival. PMID: 28346228
    4. SAMD9 mutation is associated with MIRAGE syndrome. PMID: 27182967
    5. Replication of the K1L(-)C7L(-) mutant vaccinia virus virus was enabled by multiple siRNAs to SAMD9 or WDR6. PMID: 26242627
    6. SAMD9 is down-regulated in non-small cell lung cancer. Knockdown of SAMD9 expression increased the invasion, migration and proliferation in H1299 cells in vitro and overexpression of SAMD9 suppressed proliferation and invasion in A549 cells. PMID: 25450373
    7. When SAMD9 is stimulated due to failure of the viral antagonism during infection, the resulting antiviral granules exhibit properties different from those of the canonical stress granules. PMID: 25428864
    8. Over-expression of SAMD9 is correlated with the metastasis of esophageal squamous cell carcinoma PMID: 24721411
    9. M062 also binds and antagonizes cellular SAMD9 in human cells, suggesting that SAMD9 is a novel innate antiviral factor against poxviruses. PMID: 21248034
    10. SAMD9, an IFN-gamma-responsive protein, interacts with RGL2 to diminish the expression of EGR1, a protein of direct relevance to the pathogenesis of ectopic calcification and inflammation. PMID: 21160498
    11. SAMD9 could be a key molecule to control cancer cell death by inactivated Sendai virus particle or IFN-beta treatment. PMID: 19830690
    12. Mutation analysis revealed a homozygous mutation in the SAMD9 gene (K1495E), which was found to segregate with the disease in all families and to interfere with the protein expression. PMID: 16960814
    13. SAMD9 and SAMD9L are a novel family of genes, which play a role regulating cell proliferation and suppressing the neoplastic phenotype; the human gene exists in rat, but is lost in mouse, due to a mouse specific rearrangement PMID: 17407603
    14. PIvotal role in calcification and thus implicated in various hereditary diseases such as atherosclerosis, calcinosis and autoimmune diseases. PMID: 17507861
    15. SAMD9 may have a role in the TNF-alpha signaling pathway and in the regulation of extra-osseous calcification PMID: 18094730

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  • 相关疾病：
    Tumoral calcinosis, normophosphatemic, familial (NFTC); MIRAGE syndrome (MIRAGE)
  • 亚细胞定位：
    Cytoplasm.
  • 组织特异性：
    Widely expressed. Very low levels are detected in skeletal muscle. Not detected in brain. Down-regulated in aggressive fibromatosis, as well as in breast and colon cancers. Up-regulated in fibroblasts from patients with normophosphatemic tumoral calcinosi
  • 数据库链接：

    HGNC: 1348

    OMIM: 610455

    KEGG: hsa:54809

    STRING: 9606.ENSP00000369292

    UniGene: Hs.65641