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SALL2 Antibody

  • 货号：
    CSB-PA020674GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9Y467
  • 基因名：
    SALL2
  • 别名：
    SALL2 antibody; KIAA0360 antibody; SAL2 antibody; ZNF795 antibody; Sal-like protein 2 antibody; Zinc finger protein 795 antibody; Zinc finger protein SALL2 antibody; Zinc finger protein Spalt-2 antibody; Sal-2 antibody; hSal2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human SALL2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Probable transcription factor that plays a role in eye development before, during, and after optic fissure closure.
  • 基因功能参考文献：
    1. Sall2 may play a significant role in NIT-1 cell function. PMID: 29783189
    2. Using RNA interference, the role of Spalt-like gene-2 (SALL2) was investigated in human ovarian carcinoma (OC) A2780 cells. Found downregulation of SALL2 promoted growth of the OC cell line. PMID: 29228922
    3. Understanding SALL2 function and the molecular mechanisms governing its expression and activity is critical to comprehend why and how SALL2 could contribute to disease. This knowledge will open new perspectives for the development of molecular targeted approaches in disease PMID: 28430874
    4. Sall2 enhanced the p16 minigene blocking of cell cycle progression and p16 knockdown with siRNA abolished most of the Sall2 inhibition of cell cycle progression PMID: 25580951
    5. Mechanisms of silencing SALL2 in OVCA cell lines and primary tumors and possible therapeutic approaches for ovarian carcinoma are discussed in this review. PMID: 25608837
    6. A role for SALL2 in eye morphogenesis and loss of function of the gene causes ocular coloboma in humans and mice. PMID: 24412933
    7. The SALL2 P2 promoter is hypermethylated in a majority of serous ovarian carcinomas. PMID: 23273547
    8. c-MYC may come under negative regulation by p150, consistent with the action of p150 as a putative tumor suppressor. PMID: 23029531
    9. Here, the s report that human papillomavirus type 16 E6 targets the cellular factor p150(Sal2), which positively regulates p21(WAF1) transcription. PMID: 21791360
    10. Results demonstrate binding of p150(Sal2) to two natural promoters with GC elements related to the optimal binding sequence defined in vitro and whose regulation is important for suppression of tumor growth. PMID: 21362508
    11. A CUL4/DDB1 E3 ligase containing RBBP7 as the p150(Sal2) receptor has been identified as mediating the destruction of p150(Sal2) as cells transition from a quiescent to an actively growing state. PMID: 21228219
    12. Studies indicate that vertebrate sal orthologues (spalt-like/sall) have important developmental roles during neural development and organogenesis and gentic diseases. PMID: 19247946
    13. Epidermal growth factor receptor (a potential therapeutic target) and SALL2 stained most cases of synovial sarcoma; staining was significantly less common among other tested sarcomas. PMID: 14507652
    14. Results suggest that p150(Sal2), acting in part as a p53-independent regulator of p21 and BAX, can function in some cell types as a regulator of cell growth and survival [p150(Sal2)] PMID: 15082782
    15. These data establish Sall2 as a link between p75 neurotrophin receptor and transcriptional events that regulate the growth and development of neuronal cells. PMID: 19131967

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  • 相关疾病：
    Coloboma, ocular, autosomal recessive (COAR)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Sal C2H2-type zinc-finger protein family
  • 组织特异性：
    Highest levels in adult brain (in different areas). Lower levels in heart; very low levels in kidney and pancreas. Expressed throughout the retina and lens vesicle as well as the periocular mesenchyme.
  • 数据库链接：

    HGNC: 10526

    OMIM: 216820

    KEGG: hsa:6297

    STRING: 9606.ENSP00000333537

    UniGene: Hs.416358