Rgn Antibody

1. The renal SMP30 expression levels positively correlated with plasma testosterone levels in the kidney. PMID: 27553527
2. Melatonin may produce a neuroprotective effect through its antioxidant action and by increasing hippocampal expression of SMP30 and osteopontin. PMID: 29602294
3. n. These results showed the effect of RGN in inhibiting the glycolytic metabolism in rat prostate, which was underpinned by a reduced cell proliferation index. The present findings also suggest that the loss of RGN may predispose to a hyper glycolytic profile and fostered proliferation of prostate cells PMID: 26553531
4. results highlighted the importance of RGN as a regulatory protein in Ca2+-dependent signaling pathways and its deregulation of RGN expression by Ca2+o may contribute for onset and progression of PCa. PMID: 26171977
5. RGN overexpression protects germ cell from apoptosis induced by noxious stimuli, which could be a relevant mechanism for fertility preservation in situations of oncological treatments. PMID: 24519986
6. A diminished influx of Ca2+ in epididymal tissues of RGN-overexpressing rats resulted in compromised sperm motility. PMID: 23615721
7. Regucalcin may play a pivotal role in the regulation of Ca(2+) signaling which is stimulated through a neurotransmitter in the brain neurons with aging PMID: 22652898
8. existence of multiple forms of SMP30 PMID: 21347421
9. Rgn is a novel androgen-target gene in rat testis and may have a role in male reproductive function, particularly in the control of spermatogenesis. PMID: 21680783
10. Studies indicate that regucalcin plays an important role as a regulatory protein in cell signaling system, and it is proposed to play a pivotal role in keep of cell homeostasis and function. PMID: 21431902
11. SMP30 protein levels were not altered in cortex and cerebellum of young (6 months) and old (21 months) rats. PMID: 19437547
12. effect of regucalcin, a regulatory protein of Ca2+ signaling, on guanosine-5'-triphosphatase (GTPase) activity in isolated rat liver plasma membranes was investigated; GTPase activity was significantly increased by the addition of Ca2+ PMID: 11693188
13. study demonstrates that endogenous regucalcin has a suppressive effect on DNA synthesis in the nuclei of rat renal cortex PMID: 11936841
14. endogenous regucalcin plays a suppressive role in the enhancement of nuclear DNA synthesis activity in regenerating liver with cell proliferation after partial hepatectomy in rats. PMID: 11967991
15. Role of regucalcin as an activator of sarcoplasmic reticulum Ca2+-ATPase activity in rat heart muscle PMID: 12112029
16. Role of endogenous regucalcin in transgenic rats: suppression of kidney cortex cytosolic protein phosphatase activity and enhancement of heart muscle microsomal Ca2+-ATPase activity PMID: 12210758
17. endogenous regucalcin has a suppressive effect on the enhancement of RNA synthesis activity in the nucleus of regenerating rat liver with proliferative cells PMID: 12397604
18. recombinant RGPR-p117 did not bind directly to the TTGGC sequence of the regucalcin gene promoter region in liver PMID: 12647292
19. has a suppressive effect on nitric oxide synthase activity in the liver cytosol; may play important role as a regulatory protein of NO synthase in liver cells PMID: 12647304
20. Endogenous regucalcin has an inhibitory effect on NO synthase activity in the brain cytosol of young and aged rats PMID: 12686401
21. The present study demonstrates that endogenous regucalcin has a suppressive effect on NO synthase activity in the kidney cortex cytosol of rats PMID: 12851718
22. endogenous regucalcin plays a suppressive role in the regulation of liver nuclear function in rats PMID: 12851719
23. endogenous regucalcin plays a suppressive role in the regulation of brain function in rats PMID: 12964038
24. regucalcin is expressed in rat bone marrow cells, and osteoclastic bone resorption is stimulated in regucalcin transgenic rats with increasing age PMID: 14767576
25. overexpression of regucalcin has a suppressive effect on cell death induced by TNF-alpha or thapsigargin PMID: 15108356
26. Senescence marker protein-30 is a unique enzyme that hydrolyzes diisopropyl phosphorofluoridate in the liver PMID: 15251439
27. regucalcin modulates the transcriptional process by binding to protein and DNA in the nucleus PMID: 15254778
28. Endogenous rgn suppresses protein tyrosine phosphatase activity in rat liver microsomes in transgenic rats. PMID: 15289895
29. Osteoclastic bone resporption is stimulated in regucalcin transgenic male and female rats with increasing age. PMID: 15289899
30. The effect of regucalcin in increasing superoxide dismutase (SOD) activity may not involve the sulfhydryl group of SOD. PMID: 15340235
31. hyperlipidemia is uniquely induced in regucalcin TG rats with increasing age PMID: 15375596
32. regucalcin increases superoxide dismutase activity in the heart cytosol of rats, and its effect is not related to the sulfhydryl group of enzymes PMID: 15375603
33. This study demonstrates that regucalcin directly stimulates osteoclast-like cell formation in mouse marrow culture in vitro, and that the protein stimulates bone resorption in rat femoral tissues in vitro PMID: 15578574
34. Overexpression of regucalcin suppresses sulforaphane-induced apoptotic cell death which is partly mediated through caspase-3. PMID: 15806309
35. study demonstrates that regucalcin regulates the function of osteoblastic cells, and that the protein suppresses cell differentiation and mineralization PMID: 16052480
36. Results demonstrate that overexpression of regucalcin has a suppressive effect on cell proliferation, which is mediated through various signaling pathways. PMID: 16142398
37. This study demonstrates that overexpression of RGPR-p117 enhances the expression of regucalcin mRNA and its protein level in NRK52E cells. RGPR-p117 may play a role as a transcriptional factor. PMID: 16273285
38. RGPR-p117 can enhance the regucalcin promoter activity which is related to the NF-1 consensus sequences including TTGGC motif, and its enhancing effect is partly mediated through phosphorylation and dephosphorylation PMID: 16676356
39. the SMP30 transcriptional process is redox-sensitive and its modulation occurs at DNA binding sites 3 and 5 in the promoter region PMID: 16677110
40. This study demonstrates that overexpression of regucalcin caused a remarkable increase in its nuclear localization, and that it has suppressive effects on the gene expression of L-type Ca(2+) channel or CaR. PMID: 16767692
41. Results suggest regucalcin has a role in the regulation of heart mitochondrial function. PMID: 16786169
42. Regucalcin does not have effects as the suppressor for free radical stress and the scavenger for free radical in rats. PMID: 17334641
43. Leptin mRNA expression in the adipose or liver tissues was significantly decreased in 50-week-old regucalcin transgenic rats. PMID: 17671736
44. This study demonstrates that overexpression of regucalcin suppresses the enhancing effect of insulin or glucose on the gene expression of insulin signaling-related proteins in the cloned rat hepatoma H4-II-E cells. PMID: 17912465
45. Data show that regucalcin mRNA and protein are present in rat mammary gland that estradiol down-regulates regucalcin expression. PMID: 18157649
46. regucalcin has a role in the regulation of Ca(2+)-ATPase activity in the brain mitochondria of rats PMID: 18181158
47. These studies provide novel insights into the mechanism that regulate SMP30 gene expression. PMID: 18442420

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KEGG: rno:25106

STRING: 10116.ENSRNOP00000010984

UniGene: Rn.10006