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RXRB Antibody

  • 货号：
    CSB-PA020613GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P28702
  • 基因名：
  • 别名：
    RXRB antibody; NR2B2 antibody; Retinoic acid receptor RXR-beta antibody; Nuclear receptor subfamily 2 group B member 2 antibody; Retinoid X receptor beta antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human RXRB
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE).
  • 基因功能参考文献：
    1. A fatty acid-binding protein 7/RXRbeta pathway enhances survival and proliferation in triple-negative breast cancer. PMID: 22322885
    2. polymorphism is unrelated to schizophrenia or alcoholism. PMID: 11840500
    3. Family studies revealed significant linkage disequilibrium between the RXRB alleles and a number of HLA-DPB1 alleles. PMID: 12175732
    4. Diminished RXRbeta expression might be related to prostate cancer progression. Because responsiveness to retinoic acid treatments depends on expression of different receptors, it is important to study their expression before therapy. PMID: 12514092
    5. partial dissociation of TR/retinoid X receptor heterodimer complex from the TRE is involved in the suppression of transcription induced by polychlorinated biphenyls PMID: 14985366
    6. The retinoid X receptor, beta is expressed widely and can be found in almost every tissue. PMID: 15608692
    7. In the RXRB polymorphism, no genotype TT is observed in patients with psoriasis guttata with a positive personal history of repeated tonsillitis (p(corr) = 0.001). PMID: 17341859
    8. In healthy elderly men reduction of RXRbeta expression in peripheral blood mononuclear cells might be a common feature of physiological senescence. PMID: 17916375

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    Nuclear hormone receptor family, NR2 subfamily
  • 组织特异性：
    Expressed in aortic endothelial cells (at protein level). Expressed in monocytes. Expressed in a variety of tumor cell lines.
  • 数据库链接：

    HGNC: 10478

    OMIM: 180246

    KEGG: hsa:6257

    STRING: 9606.ENSP00000363812

    UniGene: Hs.388034