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  4. RXFP1 Antibody

RXFP1 Antibody

  • 货号：
    CSB-PA875715LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of Hela cells with CSB-PA875715LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) RXFP1 Polyclonal antibody
  • Uniprot No.：
    Q9HBX9
  • 基因名：
  • 别名：
    RXFP1; LGR7; Relaxin receptor 1; Leucine-rich repeat-containing G-protein coupled receptor 7; Relaxin family peptide receptor 1
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Relaxin receptor 1 protein (17-151AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，RXFP1 Antibody (CSB-PA875715LA01HU)，的标记方式是Non-conjugated。对于RXFP1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA875715LB01HU RXFP1 Antibody, HRP conjugated ELISA
    FITC CSB-PA875715LC01HU RXFP1 Antibody, FITC conjugated
    Biotin CSB-PA875715LD01HU RXFP1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP.
  • 基因功能参考文献：
    1. Binding of relaxin to RXFP1 recruits G proteins with subsequent activation of adenylyl cyclase and elevation of cAMP. PMID: 27310652
    2. The decreased expression of the endometrial RLX receptor in women with implantation failures, both in vitro fertilization failure and recurrent pregnancy loss, suggests that RLX may play a crucial role in the structural and functional changes of the endometrium during the window of implantation. PMID: 26761440
    3. Hormone receptor expression was concentrated in the fibroblasts, and RXFP1 was also evident in blood vessels and nerves PMID: 28076930
    4. The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1 has been deciphered. PMID: 27088579
    5. RXFP1 gene expression was dysregulated in the anterior cingulate of bipolar patients. PMID: 26238605
    6. H2 relaxin amide is fully active at the relaxin receptor RXFP1 and thus dimerization is not required for biological activity. PMID: 25547165
    7. Synthetic covalently linked dimeric form of H2 relaxin retains native RXFP1 activity and has improved in vitro serum stability. PMID: 25685807
    8. Using cells stably expressing RXFP1, we found that relaxin regulation of PPARgamma activity requires accumulation of cAMP and subsequent activation of cAMP-dependent protein kinase (PKA). PMID: 25389293
    9. RXFP-1 receptors are present at the ligament, cartilage, and synovium of the TM joint, indicating that it is a potential target for relaxin. This suggests that circulating relaxin may impact joint stability. PMID: 24797570
    10. To create a tool to investigate the low-affinity interaction, a protein scaffold system displaying exoloops 1 and 2 from RXFP1 was designed. PMID: 24640555
    11. RXFP1, is a complex G-protein coupled receptor (GPCR)and has a rhodopsin-like 7 transmembrane helix region and a large ecto-domain containing Leucine-rich repeats and a Low Desnsity Lipoprotein Class-A module at the N-terminus. PMID: 24640556
    12. We have developed and assessed four microRNA against human RXFP1. PMID: 24640558
    13. The development of a quantitative high-throughput platform for an RXFP1 agonist screen. PMID: 23212924
    14. Report increased expression of RXFP1 in placenta of patients with placenta accreta. PMID: 23302396
    15. the RXFP1 receptor lacking the LDLa module binds ligand normally but cannot signal through any characterized G protein-coupled receptor signaling pathway PMID: 23926099
    16. These results provide new mechanistic insights into the binding and activation events of RXFP1 and RXFP2 by their native hormone ligands. PMID: 22973049
    17. Identification of key residues essential for the structural fold and receptor selectivity within the A-chain of human gene-2 (H2) relaxin PMID: 23024363
    18. The decreased cellular expression of relaxin-2 receptor RXFP1 in scleroderma skin might represent a pro-fibrotic factor and contribute to the substantial inefficacy of relaxin treatment in systemic sclerosis, as reported in the literature. PMID: 23043266
    19. relaxin-2 and its receptors RXFP1 and RXFP2 are expressed in GSV and their expression is significantly decreased in varicose GSV PMID: 22737225
    20. [review] The relaxin receptor RXFP1 localizes in the acrosomal region of sperm. PMID: 22180889
    21. Decrease in the expression of relaxin receptor in the placenta is related with the occurrence and development of preeclampsia. PMID: 18843967
    22. LGR7 is constitutively expressed in human endometrium, and an increased LGR7 immunostaining is demonstrated in the secretory phase, confirming the involvement of relaxin in the physiology of endometrium and suggesting its role in implantation. PMID: 21324453
    23. Endometrial expression of relaxin and relaxin receptor in endometriosis. PMID: 20655530
    24. Uncovered is a pre-assembled, constitutively active G-protein-coupled receptor signalosome, that couples the relaxin receptor, relaxin family peptide receptor 1 (RXFP1), to cAMP following receptor stimulation with sub-picomolar concentrations of peptide. PMID: 20664520
    25. These results suggest that relaxin activates PPARgamma activity and increases the overall response in the presence of PPARgamma agonists, and that this activation is dependent on the presence of RXFP1. PMID: 19712722
    26. capable of mediating the action of relaxin through an adenosine 3',5'-monophosphate (cAMP)-dependent pathway PMID: 11809971
    27. Gene expression pattern and protein localization of LGR7 receptor in human endometrium throughout the menstrual cycle. PMID: 14742692
    28. Binding to and gene expression of the LGR7 relaxin receptor changes markedly with the phases of the menstrual cycle, suggesting a specific role for the hormone in the physiology of the human uterus. PMID: 15240635
    29. Substitution of the relaxin-3 A-chain with the A-chain from insulin-like peptide 5 results in a chimeric peptide that selectively activates GPCR135 and GPCR142 over LGR7. PMID: 15465925
    30. mouse and rat LGR7 share 85.2 and 85.7% identity with human LGR7 PMID: 15566402
    31. Data describe the conformation of the relaxin-binding site of the leucine-rich G-protein-coupled receptor 7. PMID: 15695505
    32. Relaxin receptor (LGR7) increases the transcription of IGFBP-1 and prolactin in decidual and endometrial stromal cells through the promoter region containing multiple CCAAT/enhancer-binding proteins (C/EBP) binding sites. PMID: 15722441
    33. human LGR7 LDL-A module NMR studies; demonstration that calicum is required for the module to form a stable and correctly folded structure PMID: 15956684
    34. increase in LGR7 expression and H2 relaxin binding in the secretory phase of the menstrual cycle suggests a specific role for relaxin after ovulation in the human uterus PMID: 15956698
    35. Amino acid sequence analysis of the LGR7 C-terminal tail and intracellular loops revealed multiple putative phosphorylation sites, suggesting that signal switching from Gs to Gi may occur after receptor phosphorylation PMID: 15956719
    36. LGR7.10 splice variant is expressed at the cell surface, LGR7.2 is predominantly retained within cells and LGR7.1 is partially secreted. None stimulates cAMP production. PMID: 16051677
    37. Relaxin stimulates leukocyte adhesion and migration through a relaxin receptor LGR7-dependent mechanism PMID: 16303766
    38. The essential role of the LDLa module in LGR7 and LGR8 function is reported. PMID: 16963451
    39. Specific residues in the N-terminal region of the RXFP1 receptor low density lipoprotein receptor class A (LDLa) module play a key role in receptor activation. PMID: 17148455
    40. The LDL-A module of LGR7 influences receptor maturation, cell surface expression, and relaxin-activated signal transduction. PMID: 17158203
    41. The dominant-negative effects of the LGR7 splice variants expressed in the chorion and decidua could be functionally significant in the peripartal period. PMID: 18079195
    42. analysis of truncated human relaxin-2 and -3 (H2 and H3) relaxin peptides and their binding and cAMP activities on RXFP1, RXFP2, and RXFP3 PMID: 18434306
    43. N-glycosylation at Asn-303 of RXFP1 was required for optimal intracellular cAMP signaling PMID: 18533687
    44. RXFP1 is a constitutive dimer with negative cooperativity in ligand binding, and dimerization occurs through the 7TM domain, and that the ectodomain has a stabilizing effect on this interaction. PMID: 18723073
    45. The autocrine/paracrine actions of relaxin in the decidua are under additional controls at the level of expression of its receptor on the surface of its target cells. PMID: 19116340
    46. The apparent lack of classical regulation for RXFP1 and RXFP2 provides the molecular basis for the prolonged signaling and physiological actions of relaxin and related peptides PMID: 19279230
    47. Point mutations of conserved residues or complete deletion of the LDL-A module resulted in loss of the cAMP response to relaxin PMID: 19416160
    48. Ligand-mediated activation of RXFP1 and RXFP2 is a complex process involving various domains of the receptors PMID: 19416161
    49. Relaxin binds to RXFP2 with high affinity, although INSL3 has a very poor affinity for RXFP1 PMID: 19416162
    50. Data tested the hypothesis that relaxin plays a role in endometriosis by comparing the expression of relaxin mRNA and its LGR7 (RXFP1) receptor mRNA in normal human endometrium to those in samples from patients with endometriosis. PMID: 19416175

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 组织特异性：
    Expressed in the brain, kidney, testis, placenta, uterus, ovary, adrenal, prostate, skin and heart. Not detected in spleen.
  • 数据库链接：

    HGNC: 19718

    OMIM: 606654

    KEGG: hsa:59350

    STRING: 9606.ENSP00000303248

    UniGene: Hs.591686