Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. RTTN Antibody

RTTN Antibody

Unavailable
  • 中文名称：
    RTTN兔多克隆抗体
  • 货号：
    CSB-PA020581LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) RTTN Polyclonal antibody
  • Uniprot No.：
    Q86VV8
  • 基因名：
    RTTN
  • 别名：
    DKFZP434G145 antibody; Rotatin antibody; Rttn antibody; RTTN_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Rotatin protein (1509-1603AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，RTTN Antibody (CSB-PA020581LA01HU)，的标记方式是Non-conjugated。对于RTTN Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA020581LB01HU RTTN Antibody, HRP conjugated ELISA
    FITC CSB-PA020581LC01HU RTTN Antibody, FITC conjugated
    Biotin CSB-PA020581LD01HU RTTN Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in the genetic cascade that governs left-right specification. Plays a role in the maintenance of a normal ciliary structure. Required for correct asymmetric expression of NODAL, LEFTY and PITX2.
  • 基因功能参考文献：
    1. RTTN directly interacts with STIL and acts downstream of STIL-mediated centriole assembly, contributing to building full-length centrioles. PMID: 28811500
    2. We found a novel homozygous mutation in RTTN associated with microcephalic PD as well as complex brain malformations and congenital dermatitis, thus expanding the phenotypic spectrum of both RTTN-associated diseases and ciliary dysfunction. PMID: 26940245
    3. RTTN mutations cause primary microcephaly and primordial dwarfism in humans. PMID: 26608784
    4. RTTN mutations therefore link aberrant ciliary function to abnormal development and organization of the cortex in human individuals. PMID: 22939636
    5. Study characterizing mouse rotatin gene. PMID: 11900971

    显示更多

    收起更多

  • 相关疾病：
    Microcephaly, short stature, and polymicrogyria with or without seizures (MSSP)
  • 亚细胞定位：
    Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with the basal bodies at the primary cilium.
  • 数据库链接：

    HGNC: 18654

    OMIM: 610436

    KEGG: hsa:25914

    STRING: 9606.ENSP00000255674

    UniGene: Hs.654809