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  4. RTN4R Antibody

RTN4R Antibody

  • 货号：
    CSB-PA580390
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA580390(RTN4R Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA580390(RTN4R Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q9BZR6
  • 基因名：
    RTN4R
  • 别名：
    RTN4R antibody; NOGOR antibody; UNQ330/PRO526Reticulon-4 receptor antibody; Nogo receptor antibody; NgR antibody; Nogo-66 receptor antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human RTN4R
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Receptor for RTN4, OMG and MAG. Functions as receptor for the sialylated gangliosides GT1b and GM1. Besides, functions as receptor for chondroitin sulfate proteoglycans. Can also bind heparin. Intracellular signaling cascades are triggered via the coreceptor NGFR. Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton. Mediates axonal growth inhibition. Plays a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Plays a role in postnatal brain development. Required for normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated via interaction with MAG. Acts in conjunction with RTN4 and LINGO1 in regulating neuronal precursor cell motility during cortical development. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development.
  • 基因功能参考文献：
    1. Results indicate an association between RTN4R genetic variation and phenotypes linked to prefrontal function. In an hierarchical approach, a SNP (rs696884) selected based on its association with RTN4R postmortem mRNA expression in the prefrontal cortex was shown to modulate prefrontal activity during working memory processing. PMID: 28755979
    2. NgR1 ligand has a role in in oligodendrocyte progenitor cells fate in the context of a specific and common type of stroke PMID: 27956620
    3. Allelic variation of the rs701428 SNP of RTN4R was significantly associated with volumetric differences in gray matter of the lingual gyrus and cuneus of the occipital lobe. Moreover, occipital gray matter volumes were robustly associated with ultra high risk symptoms of psychosis in the presence of the G allele of rs701428. PMID: 28139055
    4. Panax notoginseng saponins provide neuroprotective effects in a rat model of cerebral ischemia and SH-SY5Y cells exposed to oxygen/glucose deprivation injury by inhibiting the overexpression of NgR1, RhoA, and ROCK2. PMID: 27288754
    5. (188)Re-NGR-VEGI has the potential as a theranostic agent. PMID: 26768609
    6. Messenger RNA expression from RTN4R in human cortical brain tissue correlated significantly with the genotypes of rs701427. Observations suggest that a functional RTN4R gene variant is associated with sporadic ALS. PMID: 26083872
    7. s highlight the structural and biochemical aspects of the interaction of Nogo receptors (R1 and R2) with myelin inhibitors such as MAG, Nogo A and OMgp.[Review] PMID: 24956133
    8. NgR1 is a neural entry mediator for mammalian reovirus.NgR1 is required for efficient infection of primary cortical neurons by reovirus. PMID: 24922571
    9. Data indicate that leucine-rich repeat neuronal protein 1 (LINGO-1) is intracellular and competes with Nogo-66 receptor (NgR) for binding to p75 neurotrophin receptor (p75NTR). PMID: 25666623
    10. This study demonistrated that alterations in DTI metrics suggest white matter microstructural anomalies of the cerebral cortex in 22q11.2DS. Structural differences in ALIC appear to be associated with the Nogo-66 receptor gene. PMID: 24321711
    11. Strong overexpression of Nogo receptor 1 in forebrain neurons impairs aspects of cognitive function but does not alter plaque load in plaque-forming transgenic animals. PMID: 22903127
    12. After optic nerve crush injury, transgenic NgR1-deficient neurons regenerate retinal ganglion axons as extensively as do zymosan-injected, macrophage-activated wild-type mice. PMID: 22728374
    13. Expression of Nogo-66 receptor in human astrocytoma is correlated with tumor malignancy. PMID: 21681431
    14. These results indicate that a lack of NgR1/2 expression promotes the adhesion of DCs to myelin. PMID: 21906273
    15. The results of this study suggested that Lack of association of the RTN4R genetic variations with risk of schizophrenia and SPEM abnormality in a Korean population. PMID: 21377214
    16. Kiaa0319-like protein interacts with Nogo Receptor 1, supporting the idea that Kiaa0319-like protein participates in axon guidance. PMID: 20697954
    17. In acute slices of adult mice, transgenic NGR suppresses long-term potentiation when locally applied to hippocampal CA1 synapses. PMID: 20844138
    18. Hypermethylation of NOGOR gene is associated with adenocarcinoma. PMID: 20524398
    19. Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth PMID: 12068310
    20. Nogo-66-R mRNA expression in humans and mice was observed in neurons of the developing nervous system; expression was downregulated in the adult spinal cord of both species, and specific expression patterns were seen in the adult brain. PMID: 12378589
    21. P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG (myelin-associated glycoprotein) and OMgp PMID: 12422217
    22. Nogo-66 receptor (NgR) proteolysis occurs within the human nervous system indicating a potential cellular mechanism for the regulation of NgR function at the level of the receptor PMID: 15331667
    23. the role of the RTN4R as a candidate gene for schizophrenia PMID: 15532024
    24. Expression of the genes encoding Nogo and its receptor, NgR, between weeks eight and 23 of human embryonic development. PMID: 15749087
    25. analysis revealed a novel disulfide structure in the C-terminal region (CT) of the NgR1, wherein the two Cys residues, Cys-335 and Cys-336, in the CT stalk are disulfide-linked to Cys-266 and Cys-309 in the LRRCT region PMID: 16342940
    26. results suggest that there is no significant association between the genetic polymorphisms in the RTN4R gene and schizophrenia in the Han Chinese population PMID: 16897606
    27. The molecular requirements for cerebral amyloid-beta peptide interaction with NgR are defined and correlated with the affinity of these polypeptides to improve spatial memory impairments in Alzheimer disease model mice. PMID: 17182778
    28. results showed that NgR immunoreactivity was present in more than 50% of the pyramidal layer cells of the CA1 to CA4 subfields of the hippocampus; results suggest that NgR may be related to the formation of tangles in Alzheimer's disease PMID: 17188332
    29. Review highlights the function of Nogo-66 receptor-1 (NgR-1) during myelin inhibition. PMID: 17959786
    30. RTN4R may modulate the genetic risk or clinical expression of schizophrenia in a subset of patients and identify additional studies that will be necessary to clarify the role of RTN4R in psychiatric phenotypes PMID: 18043741
    31. For a restricted subset of individuals diagnosed with schizophrenia, the expression of dysfunctional NGR variants may contribute to increased disease risk. PMID: 19052207
    32. We conclude that NgR1 alters the motility of immune cells exposed to myelin and may thus impact their behaviour within the CNS, particularly under conditions when immune cell activation is heightened. PMID: 19328785
    33. This review summarizes recent research that generates interest in the Nogo-66 receptor (NgR1) as a focus of study in central nervous system injury and for its function in increasing susceptibility to developing schizophrenia. PMID: 19386899
    34. Nogo-66 receptor (NgR)is identified as a high affinity receptor for BLyS; BLyS can function independently of myelin-associated inhibitors & likely serves as a redundant NgR ligand that negatively influences axonal outgrowth in the central nervous system PMID: 19439611

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  • 相关疾病：
    Schizophrenia (SCZD)
  • 亚细胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor. Membrane raft. Cell projection, dendrite. Cell projection, axon. Perikaryon.
  • 蛋白家族：
    Nogo receptor family
  • 组织特异性：
    Widespread in the brain but highest levels in the gray matter. Low levels in heart and kidney; not expressed in oligodendrocytes (white matter).
  • 数据库链接：

    HGNC: 18601

    OMIM: 181500

    KEGG: hsa:65078

    STRING: 9606.ENSP00000043402

    UniGene: Hs.30868