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RTKN Antibody

  • 货号：
    CSB-PA020565ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: RTKN antibody at 4.66μg/ml
      Lane 1: A431 whole cell lysate
      Lane 2: HepG2 whole cell lysate
      Lane 3: MCF-7 whole cell lysate
      Lane 4: Mouse brain tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 63, 62, 57 kDa
      Observed band size: 63 kDa
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA020565ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA020565ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) RTKN Polyclonal antibody
  • Uniprot No.：
    Q9BST9
  • 基因名：
    RTKN
  • 别名：
    Rhotekin antibody; Rtkn antibody; RTKN_HUMAN antibody; RTKN1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Rhotekin protein (304-563AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin structures.
  • 基因功能参考文献：
    1. Let-7a microRNA inhibits tumor cell growth and metastasis by directly targeting RTKN in human colon cancer. PMID: 27498032
    2. RTKN is upregulated in hepatocellular carcinoma.MicroRNA-152 inhibits tumor cell growth by directly targeting RTKN in hepatocellular carcinoma. PMID: 27922690
    3. The RTKN protein is associated with lung cancer in clinic samples and exerts anticancer activity in lung adenocarcinoma cells through inhibiting cell cycle progression and the DNA replication machinery. PMID: 26935528
    4. RTKN could affect the proliferation and metastasis of colon cancer by reducing expression of MCM2/3/5, CDK1/2 and PCNA PMID: 26349972
    5. suggest that interaction of S100A4 and Rhotekin permits S100A4 to complex with RhoA and switch Rho function from stress fiber formation to membrane ruffling to confer an invasive phenotypea PMID: 22964635
    6. Rho/RTKN-mediated NF-kappaB activation leading to cell survival may play a key role in gastric tumorigenesis. PMID: 15316142
    7. overexpression may play a key role in gastric tumorigenesis by conferring cells resistance to apoptosis PMID: 15480428
    8. These results suggest that the RTKN gene is involved in bladder carcinogenesis and progression in bladder carcinoma, indicating that RTKN gene could be a molecular target in cancer therapy. PMID: 15599595
    9. Lin-7B is a binding partner for Rhotekin in the human brain cDNA library PMID: 16979770
    10. SEPT9 sequence alternations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4/SEPT11 and resistance to Rho/Rhotekin-signaling PMID: 17546647
    11. Rhotekin forms a complex with vinexin and may play a role at focal adhesions. PMID: 19294487
    12. Loss of miR-145 may provide a selective growth advantage for MCF-7 by targeting RTKN. PMID: 19360360

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  • 组织特异性：
    Highly expressed in prostate, moderately in kidney, heart, brain, spleen, testis, placenta, small intestine, pancreas, skeletal muscle and peripheral blood leukocytes, and weakly in ovary, colon and thymus. Weakly expressed in all normal cell lines tested
  • 数据库链接：

    HGNC: 10466

    OMIM: 602288

    KEGG: hsa:6242

    STRING: 9606.ENSP00000272430

    UniGene: Hs.192854