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RTCA Antibody

  • 货号：
    CSB-PA819876
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    O00442
  • 基因名：
    RTCA
  • 别名：
    RTCA antibody; RPC antibody; RPC1 antibody; RTC1 antibody; RTCD1 antibody; RNA 3'-terminal phosphate cyclase antibody; RNA cyclase antibody; RNA-3'-phosphate cyclase antibody; EC 6.5.1.4 antibody; RNA terminal phosphate cyclase domain-containing protein 1 antibody; RTC domain-containing protein 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human RTCD1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
  • 基因功能参考文献：
    1. Rtc1 forms a stable binary complex with a 3'-phosphate terminated RNA, but not with an identical 3'-OH terminated RNA PMID: 19690099
  • 亚细胞定位：
    Nucleus, nucleoplasm.
  • 蛋白家族：
    RNA 3'-terminal cyclase family, Type 1 subfamily
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 17981

    OMIM: 611286

    KEGG: hsa:8634

    STRING: 9606.ENSP00000260563

    UniGene: Hs.484222