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RREB1 Antibody

  • 货号：
    CSB-PA040279
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q92766
  • 基因名：
    RREB1
  • 别名：
    FINB antibody; Finger protein in nuclear bodies antibody; Hindsight homolog antibody; HNT antibody; LZ321 antibody; Raf responsive zinc finger protein LZ321 antibody; Raf-responsive zinc finger protein LZ321 antibody; RAS responsive element binding protein 1 antibody; Ras-responsive element-binding protein 1 antibody; RREB 1 antibody; RREB-1 antibody; Rreb1 antibody; RREB1_HUMAN antibody; Zep 1 antibody; Zep-1 antibody; Zep1 antibody; Zinc finger motif enhancer binding protein 1 antibody; Zinc finger motif enhancer-binding protein 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human RREB1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters. Represses the angiotensinogen gene. Negatively regulates the transcriptional activity of AR. Potentiates the transcriptional activity of NEUROD1. Promotes brown adipocyte differentiation. May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression.
  • 基因功能参考文献：
    1. Of the 465,447 CpG sites analyzed, 12 showed differential methylation (false discovery rate <0.15), including markers within genes associated with monogenic diabetes (HNF4A) or obesity (RREB1). The overall methylation at HNF4A showed inverse correlations with mRNA expression levels, though non significant PMID: 29099273
    2. RREB1 cooperates with noncoding RNA linc-ADAMTS5 to inhibit ADAMTS5 expression, thereby affecting degeneration of the extracellular matrix (ECM) of the intervertebral disc. PMID: 28341660
    3. RREB1 and CCND1 gains are common in nail apparatus melanoma PMID: 27185405
    4. Histone modifier genes (JMJD1C, RREB1, MINA, KDM7A) alter conotruncal heart phenotypes in 22q11.2 deletion syndrome. PMID: 26608785
    5. RREB1 is a novel candidate gene for type 2 diabetes associated end-stage kidney disease. PMID: 25027322
    6. The pathway of RREB1/ZIP3/Zinc and its downregulation during oncogenesis exist to prevent the accumulation of cytotoxic levels of zinc during the development and progression of the malignant cells in pancreatic adenocarcinoma. PMID: 25050557
    7. RREB-1 overexpression results in down-regulation of hZIP1 and contributes to the loss of hZIP1 expression and zinc in prostate cancer. PMID: 21360563
    8. Thus HNT and c are functional homologs at the level of DNA binding, transcriptional regulation and developmental control PMID: 24418439
    9. Data show the transcriptional activation of the cholecystokinin gene by DJ-1 through interaction of DJ-1 with RREB1 and the effect of DJ-1 on the cholecystokinin level. PMID: 24348900
    10. RREB1 is overexpressed in colorectal adenocarcinoma tumors. RREB1 repressed miR-143/145 modulates KRAS signaling. PMID: 22751122
    11. These results support a concept that downregulation of RREB-1 causes downregulation of ZIP3, which results in decreased zinc in pancreatic premalignant and carcinoma cells PMID: 22427155
    12. Data indicate the upregulation of RREB1, PDE6B, and CD209 suggests that these proteins might play important roles in the differentiation of primitive gut tube cells from embryonic stem cells (hESCs) and in primitive gut tube development into pancreas. PMID: 21792086
    13. Data show that the combination of concurrent zinc, ZIP3, and RREB-1 changes represent early events in the development of adenocarcinoma. PMID: 21613827
    14. RREB1 transcription factor splice variants are associated with urologic cancer. PMID: 21703425
    15. KRAS and RREB1 are targets of miR-143/miR-145, revealing a feed-forward mechanism that potentiates Ras signaling PMID: 21159816
    16. Ras pathway and activation of RREB-1 are involved in hZIP1 down-regulation and may play a role in the decrease of the transporter expression in prostate cancer. PMID: 19802870
    17. The p16 promoter can be downregulated by transfected human RREB, in a Ras- or Mek-dependent manner, and that the BALB/c promoter is more sensitive than DBA/2 to regulation by RREB, a ras-responsive transcriptional element with zinc-finger binding motifs. PMID: 12700664
    18. Finb functions as a sequence-specific transcriptional repressor of the hANG gene PMID: 15067362
    19. essential to reduce cell-cell adhesion when epithelial cells within an interconnected group undergo dynamic changes in cell shape PMID: 18394891
    20. Findings provide evidence that RREB-1 participates in modulating p53 transcription in response to DNA damage. PMID: 19558368
    21. This demonstration is the first of a repressor factor of HLA-G transcriptional activity taking part in HLA-G repression by epigenetic mechanisms. PMID: 19890057

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  • 亚细胞定位：
    Nucleus speckle.
  • 蛋白家族：
    Krueppel C2H2-type zinc-finger protein family
  • 组织特异性：
    Expressed in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas. Not found in the brain.
  • 数据库链接：

    HGNC: 10449

    OMIM: 602209

    KEGG: hsa:6239

    UniGene: Hs.298248